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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Known facts about NK cell development (1993)
- IL-2 and IL-15 receptors
- IL-15 induces human NK cell differentiation
- Factors responsible for NK cells development
- KL/FL ligands and NK cells development (1)
- KL/FL ligands and NK cells development (2)
- SCF, IL-2 and IL-15 in NK cell development
- Human natural killer cell development
- Which CD34 subset develops into a NK cell?
- CD34 receptor expression
- CD34 in peripheral blood and lymph nodes
- NK precursor selectively enriched in lymph nodes
- Site of NK cell development
- NK cells in lymph nodes are CD56 bright cells
- Putative stages of human NK cell differentiation
- NK cell development in human lymphopoiesis
- IL-15 and human NK cell survival
- Adoptive transfer of NK cells
- IL-15 is required for NK cell survival in vivo
- IL-15 and NK cell development and survival
- The IL-15 transgene
- NK cell expansion in IL-15tg mice
- IL-15tg mice clinical signs and findings
- Acute T-NK lymphoblastic leukemia
- NK cell maturation
- NK cell subsets
- The immunoregulatory role of NK cell subsets
- Where does the INF-gamma signal come from?
- Macrophage and NK co-culture: LPS activation (1)
- NK cell-derived IFN-gamma
- Macrophage and NK co-culture: LPS activation (2)
- Bright cells are the primary source of IFN-gamma
- IFN-gamma production in bright and dim cells
- CD56 bright NK cells in the immune response
- Innate immunoregulator, CD56 bright
- Innate cytotoxic effector, CD56 dim
- How do inhibitory NKR work? (1)
- How does KIR work?
- How do Inhibitory NKR work? (2)
- The inhibitory receptors bind to specific epitopes
- Common epitopes that bind to these receptors
- Haplo-mismatch bone marrow transplant (BMT)
- Haplo-mismatch BMT that results in lysis
- Haplo-mismatch BMT that results in no lysis
- Haplo-mismatch BMT - no lysis outcome
- Summary of haplo-mismatch BMT
- KIR mismatch/ no mismatch
- Conclusions
- Summary
- Acknowledgments
Topics Covered
- Human NK cell development
- What factors are responsible for NK cell development?
- How does KL or FL assist IL-15 in NK cell development?
- NK progenitor, NK precursor, mature NK cell
- Only CD34dimCD45RA(+) HPC differentiate into CD56bright NK cells
- NK cells are in human lymph nodes and are CD56bright
- Putative stages of human NK cell differentiation in nodes/tonsils
- How NK cell development fits in human lymphopoiesis
- IL-15 and human NK cell survival
- Adoptive transfer of NK cells into IL-15-deficient mice
- IL-15 transgene
- Lymphoblastic leukemia
- Human NK cell subsets
- Do NK cell subsets have unique immunoregulatory roles?
- LPS activation
- NK cell-derived IFN-γ in the innate immune response
- Innate immunoregulator, CD56bright
- Innate cytotoxic effector, CD56dim
- How do inhibitory NKR work?
- How does KIR work?
- Haplo-mismatch BMT
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Talk Citation
Caligiuri, M. (2009, September 23). Natural killer cells: development, diversity and applications to human disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/OXWK2452.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Mike Caligiuri has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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