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1. Introduction
2. Outline of the talk
3. The NK cell function in cancer
4. NK cells are essential in reproduction
5. Why study NK cells?
6. Why study NK cell development?
7. What makes NK cells so versatile?
8. NK cell receptor: KIR and Ly49
9. NK cells' heterogeneity
10. NK cell subsets
11. CD27 and CD11b are maturation markers
12. Functions of NK cell subsets
13. Heterogeneity acquired during development
14. NK cell development
15. NK cell development in mice and humans
16. Cytokines' role in NK cell development
17. The IL-15 pathway
18. Cell-cell interactions (1)
19. Cell-cell interactions (2)
20. Transcription factors and lymphocyte development
21. NK cell committed precursors (NKP)
22. Intermediate maturation of NK cells
23. Terminal maturation of NK cells
24. Example of subset specialization: uterine NK cells
25. Uterine NK cells
26. Unique receptor repertoire in mouse uNK cells
27. Repertoire of MHC-binding receptors
28. Other receptors on uNK cells (1)
29. Other receptors on uNK cells (2)
30. Colucci group
31. Acknowledgements

Topics Covered

• Natural killer cells are versatile lymphocytes
• NK cells functions are important in health and disease: reproduction, cancer, transplantation, infection and autoimmunity
• Cell subsets, location and gene expression define functional heterogeneity
• Development influenced by MHC, stroma, transcription factors and cytokines
• Comparisons and contrasts between human and mouse NK cell development
• Uterine NK cells as ultimate example of specialized lineages of NK cells

Links

Series:

• Natural Killer Cell Biology

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on September 23, 2009

Financial Disclosures

• Dr. Francesco Colucci has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.