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Navigable Slide Index
- Introduction
- Outline of the talk
- The NK cell function in cancer
- NK cells are essential in reproduction
- Why study NK cells?
- Why study NK cell development?
- What makes NK cells so versatile?
- NK cell receptor: KIR and Ly49
- NK cells' heterogeneity
- NK cell subsets
- CD27 and CD11b are maturation markers
- Functions of NK cell subsets
- Heterogeneity acquired during development
- NK cell development
- NK cell development in mice and humans
- Cytokines' role in NK cell development
- The IL-15 pathway
- Cell-cell interactions (1)
- Cell-cell interactions (2)
- Transcription factors and lymphocyte development
- NK cell committed precursors (NKP)
- Intermediate maturation of NK cells
- Terminal maturation of NK cells
- Example of subset specialization: uterine NK cells
- Uterine NK cells
- Unique receptor repertoire in mouse uNK cells
- Repertoire of MHC-binding receptors
- Other receptors on uNK cells (1)
- Other receptors on uNK cells (2)
- Colucci group
- Acknowledgements
Topics Covered
- Natural killer cells are versatile lymphocytes
- NK cells functions are important in health and disease: reproduction, cancer, transplantation, infection and autoimmunity
- Cell subsets, location and gene expression define functional heterogeneity
- Development influenced by MHC, stroma, transcription factors and cytokines
- Comparisons and contrasts between human and mouse NK cell development
- Uterine NK cells as ultimate example of specialized lineages of NK cells
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Talk Citation
Colucci, F. (2009, September 23). Natural killer cell development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/VCZV7379.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Francesco Colucci has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.