Biomedical Basics

Topical vs systemic medications

  • Created by Henry Stewart Talks
Published on December 31, 2025   4 min

A selection of talks on Immunology

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This presentation will examine topical versus systemic medications with a focus on the key differences between the two, focusing on how they are administered, how they act in the body, and their respective benefits and risks. We will discuss situations where one approach is preferred over the other based on disease characteristics and patient needs. Additionally, we will examine factors affecting drug absorption, bioavailability, and potential for side effects with each type. Finally, we will highlight common uses and limitations of both topical and systemic therapies to guide effective clinical decision-making. We will explore the differences between topical and systemic medications concepts that are central to modern therapeutics. Topical medications are applied directly to a localized area such as the skin, eyes or mucous membranes and are usually intended to act where they're applied. In contrast, systemic medications are introduced into the body to be absorbed and distributed through the bloodstream affecting cells or tissues throughout the body. Knowing when and why to use each approach is crucial for maximizing treatment efficacy while minimizing side effects. The main distinction between these approaches is the intended reach of the drug's effect. Topical medications target a specific area, making them ideal for localized conditions like eczema, fungal infections or eye allergies, offering rapid relief with minimal systemic exposure. Systemic medications such as tablets,

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Topical vs systemic medications

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