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Navigable Slide Index

1. Introduction
2. NK cell recognition strategies
3. Innate immunity: the natural killer cell model
4. The immune system
5. Functions of NK cells
6. NK cells relationships with other immune cells
7. NK cell killing
8. NK cell recognition
9. Cartoon of NK cell activity
10. Molecules involved in NK-target cell recognition
11. Mouse and human NK cell - target cell synapse
12. NK recognition strategies
13. ITIM-bearing receptors
14. The KIR family
15. Inhibitory NKR
16. The family of ITIM-containing-molecules
17. ITIM-mediated inhibition of NK cell activation (1)
18. ITIM-mediated inhibition of NK cell activation (2)
19. ITIM-mediated inhibition of NK cell activation (3)
20. Model for inhibitory receptor signaling by KIR (1)
21. Model for inhibitory receptor signaling by KIR (2)
22. Two components of inhibitory signaling by ITIM
23. NK cell education via MHC class I recognition
24. Natural killer cell definition
25. Cr(51) release assay
26. NK activation and degranulation assay
27. Gated on NK cells
28. What are the naturally-occurring killer cells?
29. KIR-NKG2A- NK cells are hyporesponsive
30. KIR-NKG2A- NK cells in the mouse
31. KIR-NKG2A- NK cell phenotype
32. NK cells recognition of MHC-I in different settings
33. Role of self recognition in NK cell education
34. 2 inhibitory KIR survey > 160 HLA-C molecules
35. NK cells subsets
36. NK cells w/ inhibitory receptors for self HLA-I
37. Dual function of MHC class I recognition
38. How "natural" are natural killer cells?
39. MHC-I recognition by both KIR and TCR
40. Clinical manipulation of MHC-I recognition by NK
41. Cellular immunotherapy
42. Results of haplo-identical transplantation
43. Blocking NK cell inhibition by monoclonal Ab
44. New NK cells roles
45. Acknowledgment

Topics Covered

• Innate immunity
• Natural killer cells
• NK cell recognition strategies
• ITIM-bearing receptors
• NK cell education via MHC class I recognition
• Clinical manipulation of MHC class I recognition by NK cells

Links

Series:

• Natural Killer Cell Biology

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Vivier, E. and Ugolini, S. (2009, September 23). Education and tuning of natural killer cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/IUUW4645.
Export Citation (RIS)

Publication History

• Published on September 23, 2009

Financial Disclosures

• Prof. Eric Vivier has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Sophie Ugolini has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.