• Fundamentals of Evolution and Medicine
• 50 min
  1. Evolutionary medicine

  • Prof. Randolph Nesse
• 38 min
  2. Evolution and medicine: from the perspective of an evolutionary biologist

  • Prof. Stephen C. Stearns
• 31 min
  3. Developmental plasticity, evolution and the origins of disease

  • Dr. Mary Jane West-Eberhard
• Evolutionary Genetics
• 47 min
  4. Genetic variation and human disease

  • Dr. David Houle
• 65 min
  5. Evolutionary genetics: the detection of natural selection using molecular data

  • Dr. Mark Thomas
• 46 min
  6. Ecogenetics, evolutionary biology and human disease

  • Prof. Gilbert Omenn
• 24 min
  7. Race in genetics and medicine

  • Prof. Jeffrey Long
• 46 min
  8. Health disparities in common complex diseases: a role for genetics?

  • Dr. Kathleen Barnes
• Infectious Disease
• 44 min
  9. Bacteria and virus evolution: a model for the study of natural selection

  • Prof. Paul Turner
• 39 min
  10. Evolutionary arms races

  • Prof. Mark Pagel
• 43 min
  11. Antibiotic resistance and hospital-acquired infection

  • Dr. Carl Bergstrom
• 36 min
  12. Evolution of drug resistance

  • Dr. Pleuni Pennings
• 34 min
  13. Evolution of virulence: malaria, a case study

  • Prof. Andrew Read
• 38 min
  14. Infection and chronic disease

  • Prof. Paul Ewald
• Defenses
• 36 min
  15. Fever and related defenses

  • Prof. Matthew Kluger
• 45 min
  16. The evolutionary ecology of immunity

  • Prof. Paul Schmid-Hempel
• Novel Environmental Factors
• 39 min
  17. What did humans evolve to eat? evolutionary perspectives on human nutritional health

  • Prof. William R. Leonard
• 45 min
  18. The original human diet: what was it and should it be a model for contemporary nutrition?

  • Prof. S. Boyd Eaton
• 42 min
  19. The paleolithic lifestyle and prevention of chronic disease

  • Prof. S. Boyd Eaton
• 49 min
  20. Early nutrition, development and health: evolutionary perspectives on the metabolic syndrome

  • Dr. Christopher Kuzawa
• 31 min
  21. Evolution, human-microbe interactions and the "epidemic" of inflammation-related disorders (alias: the hygiene hypothesis)

  • Prof. Graham Rook
• 31 min
  22. Diseases of civilization: an evolutionary legacy

  • Prof. Alan Weder
• Problems Arising From Constraints and Trade-Offs
• 51 min
  23. Aging and evolutionary medicine

  • Prof. Linda Partridge
• 45 min
  24. Human aging and menopause

  • Prof. Kristen Hawkes
• 32 min
  25. Why we cook with spices: preventative darwinian medicine

  • Prof. Paul Sherman
• Sex and Reproduction
• 32 min
  26. Setting the second stage: the evolution of menopause & post-reproductive life

  • Prof. Lynnette Sievert
• 44 min
  27. Evolutionary obstetrics

  • Prof. Wenda Trevathan
• 41 min
  28. Sex differences in mortality

  • Dr. Daniel Kruger
• 46 min
  29. The endocrinology of human life history transitions

  • Prof. Peter Ellison
• 43 min
  30. Genetic conflicts in human pregnancy

  • Prof. David Haig
• 57 min
  31. Environmental effects on human reproduction

  • Prof. Gillian Bentley
• Cancer
• 54 min
  32. A darwinian eye view of cancer

  • Prof. Mel Greaves
• 56 min
  33. Viruses and cancer

  • Prof. Robin Weiss
• 38 min
  34. Connecting aging and cancer through the lens of evolution

  • Prof. James DeGregori
• 44 min
  35. Evolutionary dynamics in cancer control and cure

  • Dr. Bob Gatenby
• Specific Body Systems
• 44 min
  36. Hard tissue biology in human health and evolution: enamel biology

  • Prof. Timothy Bromage
• 19 min
  37. Hard tissue biology in human health and evolution: bone biology

  • Prof. Timothy Bromage
• 46 min
  38. Hard tissue biology in human health and evolution: craniofacial biology

  • Prof. Timothy Bromage
• 26 min
  39. Hard tissue biology in human health and evolution: life history and chronobiology

  • Prof. Timothy Bromage
• 53 min
  40. Lung biology and lung disease

  • Prof. John S. Torday
• 30 min
  41. The evolutionary web of life

  • Prof. John S. Torday
• 32 min
  42. Evolutionary considerations and the endothelium

  • Dr. William Aird
• Mental Disorders
• 38 min
  43. Evolutionary psychiatry

  • Prof. Randolph Nesse
• 48 min
  44. Evolutionary behavioural genetics and mental disorders

  • Dr. Matthew Keller
• Questions and Answers
• 57 min
  45. Audience questions about evolution and medicine

  • Prof. Randolph Nesse
• Paediatrics
• 41 min
  46. Evolutionary pediatrics

  • Dr. Paul Turke
• Microbiome
• 49 min
  47. Evolution, the microbiome, and human health

  • Dr. Joe Alcock
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  48. The hygiene hypothesis

  • Prof. Graham Rook
• 26 min
  49. Mapping motivations: evolutionary health promotion

  • Dr. Valerie Curtis
  • Dr. Robert Aunger
• 16 min
  50. Evolutionary biology of depression

  • Prof. Lewis Wolpert
• 52 min
  51. Evolutionary genetic epidemiology

  • Prof. Nicholas Schork
• 65 min
  52. Mental disorders in the light of evolutionary biology

  • Prof. Randolph Nesse
• 59 min
  53. Evolution: medicine's missing basic science

  • Prof. Randolph Nesse
• 47 min
  54. Environmental effects on human reproduction

  • Prof. Gillian Bentley

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Gene by environment interactions
3. Epidemiological findings
4. The floor plan of a typical French farmhouse
5. Asthma/allergy development and farming exposure
6. Endotoxin in bedding as a surrogate marker
7. Lymphocyte subsets
8. Lack of infections and extra Th2
9. Immunoregulatory disorders' increasing incidence
10. Asthma and type 1 diabetes occurrence
11. Disease types increasing in developed countries
12. Generating regulatory T cells
13. Treg cells development is controlled by Foxp3
14. Defective Treg in chronic inflammatory disorders
15. IL-10-secreting regulatory T cells deficiency
16. Treg might inhibit the 3 types of diseases
17. A deficit in regulation of the immune system
18. Evolution turns the inevitable into a necessity
19. Organisms implicated in the hygiene hypothesis
20. Scheme of organism in human evolutionary history
21. Avoidance of an inflammatory response
22. The dendritic cell (DC): identify friend or foe (1)
23. The dendritic cell (DC): Identify friend or foe (2)
24. The immune response to the microfilariae
25. "Old friends" alter the phenotype of dendritic cells
26. PRR and the hygiene hypothesis
27. The innate immune involvement in Treg induction
28. Responses induced by environmental organisms
29. Old friends' and Treg induction scheme (1)
30. Mouse model of allergic asthma
31. Some organisms shown to induce Treg
32. Bystander Treg suppression induced by M.vaccae
33. Old friends' and Treg induction scheme (2)
34. Bystander anti-inflammatory activity
35. Testing the efficacy of mycobacterium
36. M. vaccae active via oral route in model of asthma
37. The underlying hypothesis
38. Prebiotics, probiotics and immunoregulation
39. Do the "old friends" show activity in clinical trials?
40. A probiotics as protection against eczema
41. Treating IBD with Trichuris suis
42. Summary
43. What does the word "hygiene" actually refer to?
44. Limitations of the "hygiene hypothesis"
45. Conclusions

Topics Covered

• Definition of the hygiene hypothesis
• Gene-environment interactions
• Protection from allergic disorders by the farming environment
• Changing incidences of allergic disorders, autoimmunity and inflammatory bowel disease
• Deficient regulatory T cell activity in chronic inflammatory disorders
• Environmental microorganisms, immunoregulation and mammalian evolution
• Changing microbial exposure in developed countries
• Regulatory T lymphocytes and regulation of inflammation
• Animal models
• Cellular mechanisms
• Clinical trials

Links

Series:

• Evolution and Medicine

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on November 12, 2015

Financial Disclosures

• Prof. Graham Rook has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.