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1. Introduction
2. Copy number variants (CNVs)
3. Structural variants
4. CNVs and gene dosage
5. CNV genes
6. Mechanisms of CNV formation
7. Genome reference sequence
8. Segmental duplications (SDs)
9. Where do human segmental duplications occur?
10. Allele frequencies
11. Positive selection on gene copy number
12. Positive selection - 'survival of the fittest'
13. Nucleotide substitution selective pressure
14. Recombination varies over a chromosome
15. Variation in the efficiency of selection (1)
16. Mutational biases
17. 5%/95% split
18. Non-random model of chromosome breakage
19. G+C-rich sequence
20. G+C content in CNVs and segmental duplications
21. Larger CNVs are richer in G+C
22. Mutational biases: summary
23. Positive selection
24. Positive selection on amino acid substitution
25. Positive selection on gene copy number
26. Positive selection: frequent or rare?
27. High gene density in CNVs/SDs
28. Elevated protein evolutionary (dN/dS) rates
29. Variation in the efficiency of selection (2)
30. Recombination rate and dN/dS relationship
31. Hill-Robertson interference
32. Effects of reduced purifying selection
33. Gene contents of CNVs
34. Disease gene contents of CNVs
35. General summary
36. Exceptions to prove the rule
37. CNV evolution: the way forward
38. Acknowledgements
39. References (1)
40. References (2)

Topics Covered

• Evolution of copy number variants
• Positive or negative selection acting on copy number variable genes
• Hill-Robertson interference and its effect on the efficacy of selection
• Prediction of genes more likely, when copy number variable, to contribute to human disease

Links

Series:

• Copy Number Variation

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on August 30, 2009

Financial Disclosures

• Prof. Chris Ponting has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.