This is Lawrence Lash. I'm a professor in the Department of Pharmacology
at Wayne State University School of Medicine in Detroit, Michigan,
and the topic of my talk will be the Toxicology of the Kidney.
As you can see on this slide, there will be five major sections to the talk.
The first section, I will review a few key points about renal structure and physiology
that are important in terms of understanding why the kidney
is susceptible to toxic injury and what is unique about renal structure and function.
In the second section we will specifically address factors that are important
in determining susceptibility of the kidney to toxicant injury.
In the third and fourth sections, I will talk about different models,
first in vivo models and then various in vitro models,
that are used to discuss and study toxicology of the kidney,
and then finally as some illustrations of how chemicals can produce toxicity
in the kidney and some of the unique features as case studies,
we will review briefly some examples: heavy metals,
cadmium and mercury principally; halogenated solvents; antibiotics;
and finally analgesics.