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1. Introduction
2. Atherosclerosis
3. Areas of atherosclerotic plaques development
4. Accumulation of "dendritic cells" in the artery
5. TLR2 expression in endothelial cells
6. Early stage of the disease
7. Heterogeneity of macrophages in the plaques
8. DCs in human atherosclerotic plaques
9. Importance of monocytes in atherosclerosis
10. Hematopoietic cells involved in atherosclerosis
11. Human monocyte subsets
12. Differences between human monocyte subsets
13. Human vs. mouse monocyte subsets
14. A method for monitoring monocyte migration
15. Monocyte recruitment to plaques
16. Mouse monocyte recruitment to inflammatory sites
17. Inflammatory monocytes
18. Ly-6Clo monocytes role in plaques
19. Mannose receptor positive monocytes in plaques
20. Is the CX3CR1 allele athero-protective?
21. CX3CR1 as a survival factor
22. Progression of atherosclerosis
23. Features of advanced disease
24. Dramatic view of a necrotic core
25. Resolution of acute inflammation
26. Does this resolution occur in atherosclerosis?
27. Schematic diagram of atherosclerotic plaque
28. Leukocyte trafficking
29. Cells emigrate from lesions
30. CD68+ cell in the SMC medial layer of the artery
31. Migration of mononuclear phagocytes - method 1
32. DC-like cells fail to leave progressing plaques
33. Quantification of the surgical process
34. The effect of the surgical process
35. Migration of mononuclear phagocytes - method 2
36. Distinguishing death from trafficking
37. A schematic view of the monitoring process
38. Pulse-chase experiment
39. Late-time point of monitoring
40. Potential therapeutic targets
41. How is mobilization achieved?
42. Thank you

Topics Covered

• Initiation of atherosclerosis and importance of monocytes
• Description of monocyte subsets
• Tracking of monocyte subsets into plaques
• Macrophage subtypes and possible relevance to atherosclerosis
• CX3CR1 in atherosclerosis |Resolution of inflammation and its failure in atherosclerosis

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Gwendolyn Randolph has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.