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Innate immunity, inflammation and cancer: from bench to bedside
69 min
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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- T cell activation
- Dendritic cells (DC)
- Immune activation (1)
- Pattern recognition
- Bug recognition by Toll-like receptors in mammals
- PRRs: coupling innate and adaptive immunity
- Immune activation (2)
- Viruses induce type I/III interferons
- Induction of type I interferons is pattern recognition
- Pattern recognition of viruses
- IFN-alpha production and cytoplasmic dsRNA
- IFN-alpha/beta induction by cytoplasmic dsRNA
- Influenza virus
- Influenza NS1 protein blocks IFN-a/b production
- Cytoplasmic recognition of flu
- Induction of IFN-a does not correlate with dsRNA
- RIG-I mediated flu sensing
- Transfection with flu vRNA is sufficient to elicit IFN
- RIG-I binds directly to flu vRNA
- RIG-I mediated sensing of flu genomes
- Induction of type I/III interferons
- Recognition is specific to vRNA
- CIP abrogates the ability of flu vRNA to induce IFN
- Conclusions (1)
- 5' PPP RNA binds to the CTD of RIG-I
- Why RIG-I doesn't mediate responses to EMCV
- What about self ssRNA?
- The actual RIG-I agonist during virus infection
- IFN-a/b induction by viruses - Cytosolic pathways
- Mouse DC subsets
- pDC make lots of IFN-a in response to wild type flu
- Conclusions (2)
- pDC responses to flu require TLR7
- Endosomal recognition of viruses
- Virus recognition pathways
- TLR7 recognises poly U clusters
- TLR7 recognises self mRNA
- Conclusions (3)
- What about apoptotic cells? (1)
- Spleen DC subsets
- Scavenging by CD8-alpha positive DC
- What about apoptotic cells? (2)
- CD8a+ DC do not express TLR7 but express TLR3
- DC "decode" signs of infection within dying cells
- Detecting virally-infected cells
- Replication of some viruses generates dsRNA
- DC activation by virally-infected cells
- Virus-infected cells induce CTL responses
- CTL priming after TLR3-mediated dsRNA sensing
- Summary
- Acknowledgements
Topics Covered
- Induction of the adaptive Immunity
- Pattern recognition receptors: coupling innate to adaptive immunity
- Induction of type I IFNs: an example of recognition of viral patterns
- Cytosolic pathway for influenza virus recognition and inhibition by the viral
- NSI protein
- RIG-I-mediated recognition of influenza virus genomes and 5'-PPP-RNA
- Cytosolic 5'-PPP-RNA as a PAMP
- Plasmacytoid DC and the discovery of a second pathway for innate recognition of influenza virus
- Endosomal pathways for virus recognition: TLR7, TLR9
- TLR3 as a sensor of virally-infected cells
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Talk Citation
e Sousa, C.R. (2009, June 30). Innate recognition of viruses [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/UTCF7401.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Caetano Reis e Sousa has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
