We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Models of Investigation
-
1. Antifungal innate immunity in C. elegans
- Dr. Jonathan Ewbank
-
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity
- Prof. Jules Hoffmann
-
3. Phagocytosis in the fruit fly, Drosophila melanogaster
- Dr. Lynda Stuart
-
4. Innate immune sensing and response
- Prof. Bruce Beutler
-
5. Macrophages and systems biology
- Prof. David Hume
- Cell Types and Recruitment
-
6. Leukocyte recruitment in vivo
- Prof. Paul Kubes
-
8. Eosinophils
- Prof. Tim Williams
-
9. Dendritic cells: linking innate to different forms of adaptive immunity
- Prof. Ralph Steinman
-
11. Innate-like lymphocytes 1
- Prof. Adrian Hayday
-
12. Innate-like lymphocytes 2
- Prof. Adrian Hayday
- Recognition and Signaling
-
13. Colony stimulating factor-1 regulation of macrophages in development and disease
- Prof. E. Richard Stanley
-
14. Fc receptors: linking innate and acquired immunity
- Prof. Ken G C Smith
-
15. Phagocytosis
- Prof. Joel Swanson
-
16. Clearance of apoptotic cells and the control of inflammation
- Prof. Sir John Savill
-
17. Signaling by innate immune receptors
- Prof. Michael Karin
-
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis
- Prof. Christopher Glass
- Modulation of Effector Responses
-
19. Humoral innate immunity and the acute phase response 1
- Prof. Alberto Mantovani from humanitas.it
-
20. Humoral innate immunity and the acute phase response 2
- Prof. Alberto Mantovani from humanitas.it
-
21. Cytokines regulating the innate response
- Prof. Anne O’Garra
-
22. Arginase and nitric oxide
- Dr. Peter Murray
-
23. Novel lipid mediators in resolution of inflammation
- Prof. Charles Serhan
-
25. Cationic peptides in innate immunity
- Dr. Dawn Bowdish
-
26. Iron metabolism and innate immunity
- Prof. Tomas Ganz
- Pathogen-Host Interactions
-
27. Innate recognition of viruses
- Prof. Caetano Reis e Sousa
-
28. Type I interferons in innate immunity to viral infections
- Prof. Christine Biron
-
29. HIV-1 and immunopathogenesis: innate immunity
- Prof. Luis Montaner
-
30. Understanding and combating tuberculosis
- Prof. David Russell
-
32. Innate immunity and malaria
- Prof. Douglas Golenbock
- Health and Disease
-
33. Innate immunity in children
- Prof. David Speert
-
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis
- Prof. Sir Ravinder Maini
-
35. NOD-like receptors in innate immunity and inflammatory disease
- Prof. Gabriel Nunez
-
36. Paneth cells in innate immunity and inflammatory bowel disease
- Prof. Satish Keshav
-
37. Innate immunity in the brain in health and disease
- Prof. V. Hugh Perry
-
38. The fate of monocytes in atherosclerosis
- Prof. Gwendolyn Randolph
-
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis
- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
-
40. Monocyte/macrophages in innate immunity
- Prof. Emeritus Siamon Gordon
-
41. Innate immunity in C. elegans
- Dr. Jonathan Ewbank
-
43. NLR genes: infection, inflammation and vaccines
- Prof. Jenny Ting
-
44. Manipulation of innate immune response: lessons from shigella
- Prof. Philippe Sansonetti
-
45. Innate immunity of the lung and adaptation to air breathing at birth
- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Catabolism of arginine: substrate supply
- Catabolism of arginine: the Krebs urea cycle
- Hepatocytes vs. macrophages
- Regulation of iNOS transcription
- Importance of iNOS in mycobacterial disease
- Structure of arginases
- Evidence for Arg1 regulation by Stat6 pathway
- The type I and II IL-4 and IL-13 receptors
- Mechanism of Arg1 regulation by Stat6 pathway
- Regulation of Arg1 by the Stat3 pathway
- Catabolism of arginine: Arg1 vs. iNOS
- The substrate depletion concept
- Norvaline
- Catabolism of arginine, separation of powers
- Arginases, NO and pathogenesis (1)
- Arginases, NO and pathogenesis (2)
- Arginase and in vivo regulation of NO
- Arginase and in vivo regulation of NO (2)
- Schistosome infection and Arg1(1)
- Schistosome infection and Arg1(2)
- Schistosome infection and AAMs
- Severe periportal fibrosis, genetic components (1)
- Severe periportal fibrosis, genetic components (2)
- Macrophage Arg1 is essential for T cell response
- What about macrophage Arg1 in asthma?
- Arginase inhibitors
- Arginase & NO: unresolved questions
- Thank you
Topics Covered
- Catabolism of arginine to downstream substrates
- Catabolism of arginine in macrophages
- Nitric oxide production
- Control of iNOS at the transcriptional level
- Role of nitric oxide in immunity to intracellular pathogens with a focus on mycobacterial disease
- Structure of arginases
- Transcriptional control of arginase 1 in the liver vs. macrophages
- Arginases can suppress nitric oxide production by substrate depletion
- Pathogens use many mechanisms to regulate nitric oxide
- Arginases and alternatively-activated macrophages (AAMs)
- Schistosome infection as an example of AAM function
- AAMs and arginases
- Arginase inhibition by small molecules
- Outstanding questions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Murray, P. (2011, August 31). Arginase and nitric oxide [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/ZPMW3102.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Peter Murray has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.