Nuclear receptors comprise a superfamily of ligand- and signal-dependent transcription factors that regulate diverse aspects of reproduction, development, metabolism and immunity
Recent studies have demonstrated that a subset of nuclear receptors can co-ordinately regulate aspects of inflammation and metabolism that impact on the development of atherosclerosis and type 2 diabetes by inhibiting transcriptional responses to toll like receptors
The nuclear receptor co-repressor NCoR plays a key role in maintaining inflammatory response genes in a repressed state under basal conditions
PPARg inhibits inflammatory responses by preventing the removal of NCoR from target genes
Glass, C. (2009, May 31). Nuclear receptors at the crossroads of inflammation and atherosclerosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 2, 2022, from https://hstalks.com/bs/1297/.
Published on May 31, 2009
Prof. Christopher Glass has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.