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Navigable Slide Index

1. Introduction
2. Innate immunity and phagocytosis
3. What is innate immunity?
4. Innate immunity and the host-pathogen interaction
5. The 1908 Nobel Laureates
6. Phagocytic recognition (1)
7. Phagocytic recognition (2)
8. Phagosome maturation
9. The phagosome
10. The Drosophila phagosome
11. Drosophila as a model system
12. Drosophila as a model organism (1)
13. Toll
14. Drosophila as a model organism (2)
15. Phagocytosis during Drosophila development
16. Phagocytes in Drosophila embryos
17. Surface receptors and particle recognition
18. Receptors
19. Immune signalling receptors
20. Drosophila opsonins: TEPs
21. Scavenger receptors
22. EGF-containing receptors
23. Down's Syndrome Cell Adhesion Molecule (1)
24. Down's Syndrome Cell Adhesion Molecule (2)
25. Removal of apoptotic cells
26. Phagocytosis of cellular corpses
27. Croquemort
28. Simu and Draper
29. Pallbearer
30. Phagocytosis in host defense
31. Phagocytosis in host defense (2)
32. The contribution of phagocytosis to defense
33. RNAi screens
34. Acknowledgments

Topics Covered

• Infectious diseases remain the commonest cause of premature mortality worldwide
• The emergence of antibiotic resistant strains and the risks of bioterrorism have reinforced the importance of understanding the host-pathogen dynamic
• It is hopeful that identifying the natural mechanisms used by the host to control infection will provide new avenues for therapeutic intervention
• Model organisms such as Drosophila provide well-characterized, conserved and genetically tractable systems for exploring this dynamic
• Drosophila are amenable to not only forward and reverse genetics but also hold great promise for small molecule screening and other unbiased approaches that will uncover evolutionarily conserved components of the innate immune system

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Stuart, L. (2009, June 30). Phagocytosis in the fruit fly, Drosophila melanogaster [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/KTRU1821.
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Publication History

• Published on June 30, 2009

Financial Disclosures

• Dr. Lynda Stuart has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.