• Fundamentals of Evolution and Medicine
• 50 min
  1. Evolutionary medicine

  • Prof. Randolph Nesse
• 38 min
  2. Evolution and medicine: from the perspective of an evolutionary biologist

  • Prof. Stephen C. Stearns
• 31 min
  3. Developmental plasticity, evolution and the origins of disease

  • Dr. Mary Jane West-Eberhard
• Evolutionary Genetics
• 47 min
  4. Genetic variation and human disease

  • Dr. David Houle
• 46 min
  5. Ecogenetics, evolutionary biology and human disease

  • Prof. Gilbert Omenn
• 24 min
  6. Race in genetics and medicine

  • Prof. Jeffrey Long
• Infectious Disease
• 44 min
  7. Bacteria and virus evolution: a model for the study of natural selection

  • Prof. Paul Turner
• 39 min
  8. Evolutionary arms races

  • Prof. Mark Pagel
• 36 min
  9. Evolution of drug resistance

  • Dr. Pleuni Pennings
• 34 min
  10. Evolution of virulence: malaria, a case study

  • Prof. Andrew Read
• Defenses
• 36 min
  11. Fever and related defenses

  • Prof. Matthew Kluger
• 45 min
  12. The evolutionary ecology of immunity

  • Prof. Paul Schmid-Hempel
• Novel Environmental Factors
• 39 min
  13. What did humans evolve to eat? evolutionary perspectives on human nutritional health

  • Prof. William R. Leonard
• 45 min
  14. The original human diet: what was it and should it be a model for contemporary nutrition?

  • Prof. S. Boyd Eaton
• 49 min
  15. Early nutrition, development and health: evolutionary perspectives on the metabolic syndrome

  • Dr. Christopher Kuzawa
• 31 min
  16. Evolution, human-microbe interactions and the "epidemic" of inflammation-related disorders (alias: the hygiene hypothesis)

  • Prof. Graham Rook
• 31 min
  17. Diseases of civilization: an evolutionary legacy

  • Prof. Alan Weder
• Problems Arising From Constraints and Trade-Offs
• 51 min
  18. Aging and evolutionary medicine

  • Prof. Linda Partridge
• 45 min
  19. Human aging and menopause

  • Prof. Kristen Hawkes
• Sex and Reproduction
• 32 min
  20. Setting the second stage: the evolution of menopause & post-reproductive life

  • Prof. Lynnette Sievert
• 44 min
  21. Evolutionary obstetrics

  • Prof. Wenda Trevathan
• 41 min
  22. Sex differences in mortality

  • Dr. Daniel Kruger
• 46 min
  23. The endocrinology of human life history transitions

  • Prof. Peter Ellison
• 43 min
  24. Genetic conflicts in human pregnancy

  • Prof. David Haig
• 57 min
  25. Environmental effects on human reproduction

  • Prof. Gillian Bentley
• Cancer
• 54 min
  26. A darwinian eye view of cancer

  • Prof. Mel Greaves
• 56 min
  27. Viruses and cancer

  • Prof. Robin Weiss
• 38 min
  28. Connecting aging and cancer through the lens of evolution

  • Prof. James DeGregori
• 44 min
  29. Evolutionary dynamics in cancer control and cure

  • Dr. Bob Gatenby
• Specific Body Systems
• 44 min
  30. Hard tissue biology in human health and evolution: enamel biology

  • Prof. Timothy Bromage
• 19 min
  31. Hard tissue biology in human health and evolution: bone biology

  • Prof. Timothy Bromage
• 46 min
  32. Hard tissue biology in human health and evolution: craniofacial biology

  • Prof. Timothy Bromage
• 26 min
  33. Hard tissue biology in human health and evolution: life history and chronobiology

  • Prof. Timothy Bromage
• 53 min
  34. Lung biology and lung disease

  • Prof. John S. Torday
• 30 min
  35. The evolutionary web of life

  • Prof. John S. Torday
• Mental Disorders
• 38 min
  36. Evolutionary psychiatry

  • Prof. Randolph Nesse
• Paediatrics
• 41 min
  37. Evolutionary pediatrics

  • Dr. Paul Turke
• Microbiome
• 49 min
  38. Evolution, the microbiome, and human health

  • Dr. Joe Alcock
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  39. The hygiene hypothesis

  • Prof. Graham Rook
• 26 min
  40. Mapping motivations: evolutionary health promotion

  • Dr. Valerie Curtis
  • Dr. Robert Aunger
• 16 min
  41. Evolutionary biology of depression

  • Prof. Lewis Wolpert
• 52 min
  42. Evolutionary genetic epidemiology

  • Prof. Nicholas Schork
• 65 min
  43. Mental disorders in the light of evolutionary biology

  • Prof. Randolph Nesse
• 59 min
  44. Evolution: medicine's missing basic science

  • Prof. Randolph Nesse
• 47 min
  45. Environmental effects on human reproduction

  • Prof. Gillian Bentley
• 65 min
  46. Evolutionary genetics: the detection of natural selection using molecular data

  • Dr. Mark Thomas
• 46 min
  47. Health disparities in common complex diseases: a role for genetics?

  • Dr. Kathleen Barnes
• 38 min
  48. Infection and chronic disease

  • Prof. Paul Ewald
• 42 min
  49. The paleolithic lifestyle and prevention of chronic disease

  • Prof. S. Boyd Eaton
• 32 min
  50. Evolutionary considerations and the endothelium

  • Dr. William Aird
• 48 min
  51. Evolutionary behavioural genetics and mental disorders

  • Dr. Matthew Keller
• 57 min
  52. Audience questions about evolution and medicine

  • Prof. Randolph Nesse
• 32 min
  53. Why we cook with spices: preventative darwinian medicine

  • Prof. Paul Sherman
• 43 min
  54. Antibiotic resistance and hospital-acquired infection

  • Dr. Carl Bergstrom

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Proximal causes of disease
3. Proximate vs. ultimate causes of disease
4. Most common causes of death (U.S. 2002)
5. Assessment of the genetics effect on disease risk
6. Relative risks for common diseases in sibs
7. Relative risks for rare diseases in sibs
8. Fitness
9. Why genetic disease?
10. Why are'nt organisms optimal?
11. How natural selection alone creates disease
12. Heterozygote advantage in HLAs
13. HLAs heterozygote advantage for AIDS
14. Balancing natural selection - summary
15. Survival and aging in hunter-gatherers
16. Reproduction and aging in hunter-gatherers
17. Age-related evolutionary tradeoffs
18. Maintenance of variation by evolutionary tradeoffs
19. Mutation rate
20. Genomic mutation rate
21. Mutation-selection balance
22. All mutations cost the population
23. Deleterious mutations at APC
24. Mutation-selection balance explains APC
25. The effect of deleterious mutations
26. Genetic disease and mutation-selection balance
27. The idea of evolutionary lag
28. Changes in the human environment
29. Diseases of civilization
30. Evolutionary lag and disease
31. Gene flow and genotype-environment interaction
32. Example: sickle-cell anemia
33. Coevolutionary arms races
34. HLA and coevolutionary arms race
35. Response of HIV to HLA variation
36. Variation in malaria affects susceptibility
37. APOE and GXE interactions
38. Epistasis and GXE interactions
39. Genotype-environment interaction: summary (1)
40. Genotype-environment interaction: summary (2)
41. Unsolved problems
42. Why does the evolutionary explanation matter?
43. Optimism vs. pessimism

Topics Covered

• Proximal vs. ultimate causation
• Causes of death in modern societies
• Quantifying genetic causation
• Relative risks of common diseases
• Fitness
• Why do genetic diseases exist?
• Selection can maintain disease
• Mutation-selection balance
• Evolutionary lag
• Gene flow and genotypeenvironment interactions
• Co-evolutionary arms races
• Why evolution matters

Links

Series:

• Evolution and Medicine

Categories:

• Genetics & Epigenetics

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 16, 2020

Financial Disclosures

• Dr. David Houle has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.