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1. Introduction
2. Adipose-immune interactions
3. Paracrine adipocyte-immune cell interactions (1)
4. Adipoimmunology
5. The adipose organ in obesity
6. The immune system
7. Adipose tissue macrophages and inflammation
8. Differentiation of macrophages
9. The macrophages are highly diverged
10. Effect of obesity on adipose tissue macrophages
11. Macrophages cause insulin resistance in obesity
12. ATM polarization model
13. Macrophages induced insulin resistance in obesity
14. Future directions: ATM and adipose tissue
15. Adipose tissue lymphocytes and inflammation
16. T-lymphocytes subsets
17. CD3+ T cells are present in the adipose tissue
18. CD3+ T cells infiltrate within the adipose tissue
19. Adipose immune interactions - summary
20. Paracrine adipocyte-immune cell interactions (2)
21. Age related increased bone-marrow adipocity
22. Age related thymic adipocity
23. T cells develop in the thymus
24. T cell development
25. The effect of thymic involution
26. Current concepts on causes of thymic involution
27. Origin of thymic fat cells (1)
28. Origin of thymic fat cells (2)
29. Lineage of thymic adipocytes
30. Loss of ghrelin signaling and thymic adiposity
31. Loss of ghrelin signaling - reduction in naive T cells
32. Thymic adipocytes - summary
33. Adipose secretory products and immune cells (1)
34. Adipose secretory products and immune cells (2)
35. Effect of obesity on immune function
36. Obesity induced by monogenic leptin deficiency
37. Dietary obesity and immune-surveillance
38. Dietary obesity reduces lymphoid cellularity
39. Dietary obesity induces apoptosis of T cells
40. Influenza infection and diet-induced obese mice
41. Implications
42. Summary

Topics Covered

• Adipoimmunology
• The adipose organ in obesity
• The immune system
• Adipose tissue macrophages and inflammation
• Differentiation of macrophages
• Effect of obesity on adipose tissue macrophages
• Macrophages cause insulin resistance in obesity
• ATM polarization model
• Future directions: ATM and adipose tissue
• Adipose tissue lymphocytes and inflammation
• T-lymphocytes subsets
• CD3+ T cells are present in the adipose tissue
• Age related increased bone-marrow adipocity
• Age related thymic adipocity
• T cells develop in the thymus
• The effect of thymic involution
• Lineage of thymic adipocytes
• Loss of ghrelin signaling and thymic adiposity
• reduction in naive T cells
• Adipose secretory products and immune cells
• Effect of obesity on immune function
• Obesity induced by monogenic leptin deficiency
• Dietary obesity reduces lymphoid cellularity
• Dietary obesity induces apoptosis of T cells
• Influenza infection and diet-induced obese mice

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Immunology
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 7, 2009

Financial Disclosures

• Dr. Vishwa Dixit has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.