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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome biorientation in yeast
- Prof. Mike Stark
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- What is chromosome bi-orientation?
- A model of chromosome bi-orientation
- Chromosome bi-orientation and cell division
- Cohesin role during chromosome bi-orientation
- Sister chromatid attachment to microtubules
- The budding yeast as a model for bi-orientation
- Monitoring sister centromeres in yeast
- Metaphase-arrested cell
- Bi-orientation leads to tension
- Special structure of chromatid under tension
- Kinetochore capture - a necessary pre-requisite
- Kinetochore capture in yeast
- Kinetochore capture: yeast vs. metazoans
- Achieving chromosome bi-orientation
- Geometry-dependent mechanism?
- Correction mechanism?
- Yeast Ipl1p kinase
- Chromosomes fail to bi-orient in ipl1 mutants
- Role of Ipl1 in chromosome bi-orientation (1)
- Role of Ipl1 in chromosome bi-orientation (2)
- How might Ipl1p kinase promote bi-orientation?
- Bi-orientation without back-to-back geometry (1)
- Bi-orientation without back-to-back geometry (2)
- Conclusions from mini-chromosomes studies
- Ipl1p - substrates and mechanisms
- The yeast chromosomal passenger complex
- Models for tension-sensing
- CPC and kinetochores in MCD1 mutant
- Targets of Ipl1p kinase at the kinetochore
- Structure of the yeast kinetochore
- The Ndc80 complex
- Ipl1p phosphorylates Ndc80
- DASH/Dam1p complex
- Dam1 alignment - S.cerevisiae vs. S. castellii
- Mutations in Dam1 and their consequences
- Model for Ipl1 function in promoting bi-orientation
- Targets of Aurora B in other organisms
- Other components required for bi-orientation
- Ipl1p, bi-orientation and spindle checkpoint
- Conclusions
Topics Covered
- What is chromosome biorientation and why is it important?
- Failure to bi-orient a chromosome will lead to mis-segregation/aneuploidy
- Modes of sister chromatid attachment to spindle microtubules
- The budding yeast (Saccharomyces cerevisiae) as a model for studying chromosome bi-orientation
- Monitoring sister centromeres on individual yeast chromosomes
- Kinetochore capture
- Achieving chromosome bi-orientation: mechanisms
- Geometry-dependent mechanism or a correction mechanism?
- Yeast Ipl1p kinase
- Chromosomes fail to bi-orient with high frequency in Ipl1 mutants
- How might Ipl1p kinase promote bi-orientation?
- Yeast chromosomes can bi-orient without the need for back-to-back geometry
- How does Ipl1p kinase promote bi-orientation?
- The yeast chromosomal passenger complex
- Models for tension-sensing
- What are the targets of Ipl1p kinase at the kinetochore?
- Model for Ipl1 / Aurora function in promoting bi-orientation
- Does Aurora B have similar targets in other organisms?
- Other components required for bi-orientation
- Ipl1p kinase may coordinate chromosome bi-orientation and spindle checkpoint activation
Links
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Talk Citation
Stark, M. (2009, May 6). Chromosome biorientation in yeast [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 26, 2021, from https://hstalks.com/bs/1262/.Publication History
Financial Disclosures
- Prof. Mike Stark has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Chromosome biorientation in yeast
Published on May 6, 2009
54 min