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Navigable Slide Index

1. Introduction
2. The centrosome discovery
3. Centrosome function
4. Centrosome is the primary MTOC of an animal cell
5. Microtubule nucleation
6. Gamma-tubulin ring complexes
7. Centrosomes and the interphase microtubuli
8. Centrosomes and the bipolar mitotic spindle
9. Microtubules of the mitotic spindle
10. Centrosomes and ciliogenesis
11. Essential and non-essential centrosome functions
12. Centrosome structure
13. Centrosomes composition: centrioles and PCM
14. Centrioles and basal bodies
15. The centrosome duplication cycle
16. Fluorescence image of cell in interphase
17. Fluorescence image of cell in mitosis
18. Fluorescence image of cell in cytokinesis
19. The importance of centrosome duplication
20. Centrosome duplication coordinated with cell cycle
21. Regulation of centrosome duplication
22. Key events in the centrosome duplication cycle
23. Two pathways for centrosome duplication
24. Molecular control of templated centriole duplication
25. Proteins involved in templated centriole duplication
26. Coordinating centriole duplication, DNA replication
27. De novo basal body/centriole formation pathways
28. Uncoupling centrosome duplication from cell cycle
29. Formation of multipolar spindles
30. Regulation of centrosome separation
31. Intercentriolar linker links interphase centrosomes
32. Cell cycle dependent centrosome cohesion
33. Molecular components of the intercentriolar linker
34. Consequence of centrosome separation defects
35. Centrosomes in cancer cells
36. Supernumerary centrosomes and cancer cells
37. Supernumerary centrosomes in cultured cells
38. Centrosome defects in tumours
39. Aneuploidy and chromosome instability
40. How do cancer cells acquire multiple centrosomes
41. Fates of cells with supernumerary centrosomes
42. Summary
43. Acknowledgments

Topics Covered

• The centrosome as a microtubule organizing centre
• Microtubule nucleation
• Mitotic spindle organization
• Centrosomes and ciliogenesis
• Centrosome structure and composition
• The centrosome duplication cycle
• Regulation of centrosome duplication
• Centriole formation pathways
• Centriolar cohesion
• Regulation of centrosome separation
• Centrosome overduplication in cancer cells
• Aneuploidy and chromosome instability
• Models for the acquisition of supernumerary centrosomes

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Andrew Fry has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.