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1. Introduction
2. Control of cell proliferation
3. The budding yeast: Saccharomyces cerevisiae
4. Why yeast?
5. The budding yeast life cycle
6. Placement of START in the cell cycle
7. Observing START
8. The concept of "START" - The G1 checkpoint
9. Genetic characterization of START
10. Interdependency of Cdk1 with START regulators
11. Cyclin-dependent protein kinase (CDK)
12. The cyclin/CDK cycle
13. G1 cyclin/CDK is essential for START
14. The role of CDK in START
15. Periodic expression of Far1 and cyclins
16. Cell cycle regulators accumulation in G1
17. The molecular correlate of START
18. G1-specific transcription
19. Phosphorylation of Whi5 by Cln3
20. Repression of MBF and SBF as cells exit G1
21. Conservation of G1-specific transcription regulators
22. G1-specific gene expression and human cancer
23. The molecular determinant of START - summary
24. Physiological regulators of START
25. Mating generates diploid cells from haploid cells
26. Cells of opposite mating types can conjugate
27. Responses elicit by mating pheromone cascade
28. Mating pheromone signaling pathway
29. Far1 activation by mating pheromones
30. Regulation of START by other stimuli
31. Control of START by cell size
32. The molecular basis for the Sizer and Timer
33. Possible signals for achieving minimum cell size
34. Summary
35. Related reading

Topics Covered

• Control of cell proliferation
• The budding yeast: Saccharomyces cerevisiae
• Why yeast?
• The budding yeast life cycle
• Placement of START in the cell cycle
• Observing START
• The G1 Checkpoint
• Genetic characterization of START
• Interdependency of Cdk1 with other regulators of START
• Cyclin-Dependent Protein Kinase (CDK)
• The cyclin/CDK cycle
• G1 cyclin/CDK is essential for START
• The role of CDK in START
• Cell cycle dependent expression of Far1 and cyclins
• Periodic accumulation of yeast cell cycle regulators
• The molecular correlate of START
• G1-specific transcription
• G1-specific gene expression and human cancer
• The molecular determinant of START
• Physiological regulators of START
• Mating generates diploid cells from two haploid cells
• Cells of opposite mating types can conjugate
• Stimulation of the mating pheromone cascade elicits three primary responses
• Mating pheromone signaling pathway
• Mating pheromone promotes G1 phase arrest by activating the Cln/CDK inhibitor, Far1
• Regulation of START by other stimuli
• Control of START by cell size
• The molecular basis for the sizer and timer
• What is the signal for achievement of minimum cell size?

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Microbiology

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Prof. Curt Wittenberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.