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1. Introduction
2. The goal of evolutionary/Darwinian medicine
3. Medicine uses some evolution
4. But much is missing
5. Some general principles
6. General principles corrected
7. Schools that include topic in medical curriculum
8. Evolutionary biology faculty in medical schools
9. Gertrude Stein on her deathbed
10. Volnerability of the body and natural selection
11. Natural selection is too weak to improve the body
12. The new answer
13. The dawn of Darwinian medicine
14. A picture of George Williams
15. Disease and evolution
16. An example: the eye
17. First half of medical school: an organ of perfection
18. In the clinic: a botched design
19. Designing a better body in one afternoon
20. Natural selection
21. Two kinds of explanation
22. Two complementary explanations
23. Tinbergen's 4 questions
24. Tinbergen's 4 questions organized
25. Four questions about honeycreeper beaks
26. The 30 cm spur of the star orchid and the moth
27. Darwinian medicine
28. How is evolution useful for medicine?
29. Direct applications in the clinic?
30. Evolution and medicine - branches
31. Why we get sick
32. Evolutionary questions about disease
33. Six reasons why diseases exist
34. 1. Mismatch
35. Atheroma
36. Cholesterol levels
37. Breast cancer
38. Genetic "quirks"
39. Myopia
40. Mean negative affect scores vs. BDNF genotype
41. Hygiene hypothesis
42. Signals of recent selection
43. BP, genes, latitude and environment
44. 2. Competition with other organisms
45. Streptococcal infection
46. Antibiotic resistance of 480 soil bacterial isolates
47. Virulence
48. 3. Every trait is a trade-off
49. Malaria in Melanesia
50. Alpha + thalassemia protects against malaria
51. Gout syndrome: uric acid crystals in joints
52. Billirubin: highly toxic compound, then why?
53. 4. Constraints
54. Terrestrial whales
55. Path dependence
56. 5. Health is not selection's goal
57. Senescence and pleiotropy
58. The strength of selection
59. Force of selection against senescence
60. If mortality stayed at early adulthood rates
61. The vulnerable sex
62. Male to female mortality ratio
63. Developmental pleiotropy a prediction
64. 6. Defenses and suffering
65. Charles Darwin
66. Defenses vs. defects
67. Defense regulation
68. The smoke detector principle (1)
69. What if the cue is unreliable?
70. How loud should the noise be before you run?
71. Optimal response threshold
72. Should you flee from a noise?
73. A threat and response
74. Being killed greatly decreases future fitness
75. Panic disorder
76. The smoke detector principle (2)
77. A phylogeny of emotions
78. A conclusion about defenses
79. Six reasons for vulnerability
80. Main conclusions
81. Some of many implications
82. Overall conclusion
83. The state of Darwinian medicine
84. www.EvolutionAndMedicine.org

Topics Covered

• How evolution is useful to medicine
• Why doctors don't know evolution
• The body: perfect and pathetically flawed
• Proximate and evolutionary explanations
• Explain vulnerability, not diseases
• Six reasons for vulnerability
• Darwinian medicine growing fast

Links

Series:

• Evolution and Medicine

Categories:

• Clinical Practice
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Randolph Nesse has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.