Hello, my name is Philipp Scherer.
I market Touchstone Diabetes Center at the University of Texas,
Southwestern Medical Center, in Dallas Texas.
It is my pleasure to talk to you today about
the endocrine functions of adipose tissue with
a particularly emphasis on the adipocyte-specific secretory protein, adiponectin.
I will structure my talk into four different sections.
I will start out by discussing adipose tissue as an endocrine organ.
We'll go through some hallmarks of dysfunctional adipose tissue and
then follow up with our general discussion
of fat-derived factors that we generally refer to as adipokines.
Finally, I'll spend a significant amount of time
discussing the physiological role and the use of adiponectin as a clinical marker.
Adipose tissue is ubiquitously distributed and system wide,
there's not a single cell that's not affected
directly or indirectly by fat-derived factors.
These factors include lipid factors as well as protein-based hormonal factors,
and key tissues that have been studied over the years include the vasculature, liver,
the heart, pancreatic beta cells,
as well as the reproductive tract,
the brain, and muscle.
Predictably, fat-derived factors have a profound impact on energy metabolism.