• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

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Navigable Slide Index

1. Epigenetics - Definition
2. Epigenetic marks
3. Marking DNA by cytosine methylation
4. Cytosine methylation evolutionarily volatile
5. DNA methylation patterns
6. Pattern of mammalian DNA methylation
7. Questions of patterning
8. Maintenance of genomic CpG methylation patterns
9. De novo methylation of CpG islands
10. De-methylation of the paternal pronucleus
11. De-methylation of interleukin-2 promoter in T helper
12. What determines the pattern ?
13. CpGs in mammalian transposons
14. Ciona intestinalis/Ascidian larva
15. Stable mosaic of meth./non meth. domains (A)
16. Stable mosaic of meth./non meth. domains (B)
17. Non-methylated transposable elements
18. Immunity to DNA methylation
19. What triggers DNA methylation?
20. The consequences of DNA methylation
21. Deamination of cystocine & 5-methylcytosine
22. 5-Methylcytosine is an endogenous mutagen
23. Reading the methylation signal (A)
24. Reading the methylation signal (B)
25. Methyl-CpG binding protein family
26. MBD2 - the ancestral MBD protein
27. MeCP1: detectable in crude nuclear extracts
28. MeCP1 = MBD2 & NuRD complex
29. Biological role of MBD3
30. Differentiation of nave T helper cells
31. De-repression of interleukin-4 & interferon-g
32. In the absence of Mbd2:
33. Gene slicing depends on cooperation (A)
34. Gene slicing depends on cooperation (B)
35. DNA methylation & disease - What can go wrong? (A)
36. DNA methylation & disease-What can go wrong? (B)
37. Methyl-CpG binding protein family
38. Rett Syndrome
39. Rett Syndrome mutations in the MECP2 gene
40. MBD of MeCP2 docked with methylated DNA
41. Murine Bdnf gene modulated by MeCP3
42. Murine Bdnf gene modulated by MeCP2 (B)
43. Conclusions

Topics Covered

• DNA methylation as an epigenetic mark
• location and patterns of methylated and nonmethylated CpG sites in the vertebrate genome
• factors determining DNA methylation patterns
• association of DNA methylation with stable gene silencing, e.g. methylation of CpG islands on the inactive X-chromosome, ensures long term repression of associated genes
• recruitment of corepressors that impose a silent chromatin structure
• repulsion of transcriptional activators by methyl-CpG leading to gene silencing
• the link between human disorders, including cancer, Rett Syndrome and ICF syndrome, and defects in the DNA methylation system

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on June 22, 2016

Financial Disclosures

• Prof. Adrian Bird has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.