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1. Introduction
2. Locations in brain activated by pain stimuli
3. Spinal thalamic tract (1)
4. Spinal thalamic tract (2)
5. Spinal thalamic tract cells respond to pain
6. Different cells in the spinal thalamic tract
7. Recording from cells in the superficial dorsal horn
8. inhibition by warming
9. Cold receptive cluster and nociceptor specific cells
10. Lamina I vs. deep laminar neurons of origin
11. Different cells respond to different pain stimuli (1)
12. Different cells respond to different pain stimuli (2)
13. Evidence against a pain specific thalamic nucleus
14. Calbinden staining and STT staining do not overlap
15. Selective injection- VP nucleus
16. Activity in the thalamic relay to cortex
17. Recordings in a human thalamus
18. Anatomy of the somatic sensory thalamus
19. A cell in VC responding to painful stimuli
20. A cell in VC responding to brush
21. Firing is not always at a steady rate
22. Thalamocortical non-linearities
23. Intense bursts of firing occur post inhibition
24. Thalamocortical circuity
25. Pain evoked by electric stimulation
26. Stimulation of many cells in one patient
27. Different stimulation sites overlap
28. Effect of different pattern on the evoked sensation
29. Visual analog scale of pain intensity
30. Transmission of visceral sinals in the spinal cord
31. Neuron response to different organ distension (1)
32. Somatovisceral convergence in the lateral thalamus
33. Sites of cardiac pain evoked by stimulation
34. Which words describe the sensation you feel?
35. Effects of thalamic lesions
36. Effect of local anasthetic injection
37. Studies of the cortex
38. WDR cell responses
39. Distribution of LEPs
40. Intensity of LEP should vary with intensity of pain
41. LEPs, v-SEPs, e-SEPs located on similar areas
42. Cells responding to noxious stimuli
43. Nociceptive input to the cortical projection zones
44. BESA estimate of dipole locations
45. Lesions and parasylvian pain related activity
46. Lesion evidence: the insula
47. Insular lesions associated with pain tolerance
48. Responses to attention
49. ACC lesions - associated with higher pain intensity
50. Functional connectivity and networks
51. SI vs. parasylvian - attention condition
52. Prestimulus PLV- attention and distraction
53. Post prestimulus PLV- attention and distraction
54. Task-specific functional connectivity

Topics Covered

• Areas of the brain stimulated by different kinds of pain stimuli
• Mechanisms of activation in the thalamus and cortex
• The spinothalamic tract
• Physiological differences between different parts of the spinothalamic tract
• Superficial dorsal horn
• Response to temperature
• Laminar 1 vs. deep laminar neurons of origin
• Evidence against a separate thalamic nucleus specific to pain and thermal sensation
• Activity in the thalamic relay to cortex
• Single unit and microstimulation analysis of somatic sensory thalamus
• Stimulus evoked spike trains composed of single spikes and bursts
• Thalamocortical non-linearities
• Thalamocortical circuitry
• Binary, labelled non-linear and analog pathways traversing the thalamus: what are the cortical targets?
• Transmission of visceral signals in the spinal cord
• Effects of thalamic lesions
• Distribution of LEPs
• Is there nociceptive input to the cortical projection zones of nuclei?
• BESA estimate of dipole location
• Insular lesions may be associated with increased pain tolerance
• ACC lesions are associated with increased gain of pain intensity and unpleasantness rating
• Functional connectivity and networks
• Synchrony assessed by phase locked value
• Pre-stimulus synchrony predicts pain vs. non-painful sensations
• Task-specific functional connectivity

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 22, 2009

Financial Disclosures

• Prof. Frederick Lenz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.