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1. Introduction
2. Pathophysiology of cerebral ischemia
3. Extent and time course of damage in ischemia
4. Penumbra concept of cerebral ischemia
5. CBF thresholds
6. Imaging of blood flow and metabolism
7. Multiparametric imaging of focal ischemia
8. Flow dependence of biochemical changes
9. Viability thresholds of cerebral ischemia
10. Biochemical imaging of ischemic penumbra
11. Infarct growth into the penumbra
12. Dynamics of infarct growth
13. Summary (1)
14. Take-home message
15. Evolution of ischemic injury
16. Propagation of ischemic damage
17. Excitotoxic cascade
18. Glutamate toxicity
19. Glutamate receptors blockage decreases infarction
20. Validity of stroke models?
21. Other mechanisms as targets for treatment
22. Apoptosis cascade as a therapeutic target
23. Cell death in ischmia
24. TUNEL does not colocalize with penumbra
25. Mechanisms involved in ischemic cell demage
26. Evolution of ischemic injury (1)
27. Peri-infarct depolarizations
28. Spreading depression induced injury progression
29. Correlation between DC and infract volume
30. Evolution of ischemic injury (2)
31. Early cytotoxic brain edema
32. Late vasogenic brain edema
33. Summary (2)
34. General conclusion
35. Thresholds for preservation of function & structure
36. Compartments of infarct development
37. Before treating acute ischemic stroke
38. Role of functional imaging in stroke
39. Is there salvageable tissue?
40. Development of infarction in experimental models
41. Injury from transient ischemia
42. Recovery from transient ischemia
43. Oxygen extraction fraction, left lateral view
44. Focal pathophysiological changes
45. Focal pathological findings
46. PET: acute ischemic stroke
47. Development of infarction
48. Reversible ischemia
49. Imaging the penumbra with PET
50. Flumazenil imaging
51. Flumazenil binding and final infarct
52. FMZ imaging is similar to O2 metabolic imaging
53. FMZ imaging with thrombolysis
54. Prediction curves for relative CBF and FMZ binding
55. Prediction limits
56. Image processing (1)
57. Image processing (2)
58. Image processing (3)
59. Subcompartments of final infarction
60. How much tissue can be salvaged?
61. Treatment strategies for ischemic stroke
62. Conclusion
63. Acknowledgements
64. Special thanks
65. Best wishes from Cologne

Topics Covered

• Cerebral ischemia
• Stroke
• Pathophysiology of ischemic brain damage
• Penumbra
• Reversible vs. irreversible brain damage
• Imaging of development of ischemic damage
• Imaging of development of ischemic damage in experimental models and patients with stroke

Links

Series:

• Cerebrovascular Disease

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 27, 2008

Financial Disclosures

• Prof. Wolf-Dieter Heiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.