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The Blood-Brain BarrierUnderstanding the regulatory gatekeeper between brain and body

Launched March 2008 Updated June 2021 27 lectures
Summary

The blood-brain barrier (BBB) is the multi-dimensional neurovascular interface between the central nervous system (CNS) and the rest of the body. With an immense surface area, it functions as a gate-keeper to the CNS, preventing easy passage of substances that may endanger the homeostasis of the milieu.... read more

Unfortunately, the BBB may hinder the delivery of many substances to the brain and spinal cord that might improve neurodegenerative, ischemic and traumatic disorders of the CNS. Yet the dogma of the BBB providing a static barrier has been shattered by the demonstration of saturable transport systems into the CNS for many substances including some ingestive peptides, cytokines and neurotrophins.

This series of talks will explain the composition of the BBB, how it functions and how it might be manipulated to facilitate treatment of CNS disorders.

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Structure of the blood-brain barrier (2 Lectures)  

Nutrient transport (1 Lecture)  

Peptides and proteins (2 Lectures)  

Overcoming the blood-brain barrier obstacle (3 Lectures)  

Diseases involving the blood-brain barrier (3 Lectures)  

Latest Developments in the Field (3 Lectures)  

Archived Lectures *These may not cover the latest advances in the field (13 Lectures)  

Neurotrophins and the BBB
36 min
  • Prof. Weihong Pan
  • BioPotentials Sleep Center, USA
Archived
Vasoactive peptides and the blood-brain barrier
52 min
  • Prof. Maria Deli,
  • Prof. Bela Kis
Archived
In vivo systems
42 min
  • Prof. Quentin Smith
  • Texas Tech University Health Sciences Center, USA
Archived
CNS-drug design
46 min
  • Prof. Quentin Smith
  • Texas Tech University Health Sciences Center, USA
Archived
Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier
43 min
  • Prof. Tetsuya Terasaki
  • Tohoku University, Japan
Archived
Stroke and the BBB
23 min
  • Prof. Marilyn Cipolla
  • University of Vermont, USA
Archived
Barrier mechanisms in the developing brain: mechanisms and misunderstandings
54 min
  • Prof. Norman Saunders
  • University of Melbourne, Australia
Archived
Barrier mechanisms in the developing brain: protection or vulnerability?
57 min
  • Prof. Norman Saunders
  • University of Melbourne, Australia
Archived
In vitro models of the blood-brain barrier
43 min
  • Prof. Pierre-Olivier Couraud
  • Institut Cochin, Paris, France
Archived
Glucose transport across the blood-brain barrier
41 min
  • Prof. Luc Leybaert
  • Ghent University, Belgium
Archived
The blood-brain barrier and brain tumors
53 min
  • Dr. Olaf van Tellingen
  • The Netherlands Cancer Institute, The Netherlands
Archived
Cellular composition of the blood-brain barrier
37 min
  • Prof. N. Joan Abbott
  • King's College London, UK
Archived
Features of mammalian CNS barrier systems
48 min
  • Prof. Conrad Johanson
  • Brown University Medical School, USA
Archived