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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Neurotrophins and their receptors
- Characteristics of neurotrophins
- Neurotrophin receptors and signals
- Other neurotrophic proteins
- Neurotrophic peptides (naturally occurring)
- Neurotrophic support to the brain and spinal cord
- Blood-brain barrier and blood-spinal cord barrier
- Characteristics of the blood-brain barrier
- NGF 30 minutes after iv injection
- Comparison of neurotrophins kinetic data
- Octanol/PBS partition coefficient
- Capillary depletion 10 minutes after iv
- Saturable transport of NGF
- Saturable transport of NT3
- BDNF 60 minutes after iv
- BDNF entering brain parenchyma
- Saturable transport of BDNF
- Efflux of BDNF
- Classical neurotrophins
- GDNF 30 minutes after iv administration
- Influx of GDNF
- GDNF is relatively stable in circulation
- Influx transport of CNTF
- CNTF degradation assay
- CNTF - conclusion
- LIF
- LIF mainly shows reversible vascular binding
- LIF influx is a saturable process
- Kinetics of LIF influx in the spinal cord
- Examination of LIF influx by in situ brain perfusion
- Blocking antibody, but not CNTF, inhibits LIF influx
- LIF: no efflux transport
- Growth hormone: lack of saturable transport
- In situ brain perfusion data for the growth hormone
- Growth hormone: uptake by brain parenchyma
- Co-injection of insulin and growth hormone
- Insulin does not interfere with IGF1 transport
- Inhibition of IGF-1 transport by insulin
- EGF: example of a neurotrophic peptide
- Recovery of EGF from brain after iv administration
- EGF distribution between brain and blood
- TGFalpha shares the transport system with EGF
- Anti-EGFR Ab showed no effect on EGF influx
- EGFR knock-out mice maintain transport function
- There is no efflux transport system for EGF
- Enhancing CNS delivery of peptides and proteins
- BBB-targeting of BDNF in rats
- Neuroprotective effect of bFGF/OX26-SA conjugate
- Application of a BBB-penetrating form of GDNF
- Effects of IGF-I intranasal administration
- Left forepaw-placing test
- Vestibulomotor function in the beam balance test
- BDNF gene delivery into the CNS
- BDNF levels in transplanted mouse brain cells
- Limitations
- Other means for neuroprotection and regeneration
- Summary
- References
Topics Covered
- Overview of neurotrophins
- CNS physiology and roles in neuroregeneration
- The blood-brain barrier (BBB)
- General strategies to enhance CNS delivery
- Progress on neurotrophin delivery across the BBB
- Limitations and future directions
Links
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Talk Citation
Pan, W. (2008, March 1). Neurotrophins and the BBB [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/GGYH7817.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Weihong Pan has no commercial/financial relationships to disclose