Other Talks in the Series: The Blood-Brain Barrier

We are Juan L. Blazquez, Montserrat Guerra and Esteban Rodriguez. The present talk is an update of our former talk of 2008. All the previous evidence and some new findings continue to support the concept of the tight hypothalamic blood brain-barrier. Furthermore, we now provide evidence that peripheral peptides can reach their brain targets via the cerebrospinal fluid through a specific transport systems localized at the choroid plexus and probably in hypothalamic tanycytes. The blood brain-barrier is an efficient system to prevent the nervous tissue to be directly exposed to the blood stream. There are, however, discrete brain areas where neural cells, either neurons or specialized glia may establish an open communication with blood capillaries. For this to occur without making the blood brain-barrier leaky, these windows through which the brain looks at the internal milieu, must have a spatial organization. The subject to the present talk is about one of these brain windows, the Median Eminence.

Tanycytes allow a tight BBB in the median eminence

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