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Printable Handouts
Navigable Slide Index
- Introduction
- Barrier mechanisms in the developing brain
- The brain barriers - overview
- Claude Bernard - the brain's internal environment
- Alcian blue stain of gut, eye and brain
- Paul Ehrlich
- Edwin Goldmann
- Max Heinrich Lewandowsky
- Tight junctions and their function in the BBB
- Hugh Daveson
- The brain barriers in the embryo
- Outline
- Brain development - different species
- Trypan blue dye of fetal guinea pig
- Dye injection to the CSF, Pig 9mm CRL embryo
- Stern - Dye injection in newborn animals
- Newborn mouse injected with Trypan blue
- Colloids and crystalloids dyes
- Freeze fractures in brain development
- Freeze fractures of blood vessel tight junctions
- Tight junctions permeability in developing brain
- Biotin labeled molecules for permeability testing
- Junctions are functionally tight in early stages (1)
- Junctions are functionally tight in early stages (2)
- Junctions are functionally tight in early stages (3)
- A possible trans-cellular route of entry
- Tightness of blood vessels in developing brain
- P1 Monodelphis, stained with anti-albumin
- Mechanisms of barriers induction
- Molecular basis of induction process
- Radio-labeled permeability markers experiments
- The sheep placenta
- Marker levels after IV injection - plasma and CSF
- CSF:plasma ratio
- Experiments with marsupial new born
- Brain development of a newborn opossum
- CSF:plasma ratio in opossum (1)
- Brain:plasma ratio in opossum
- CSF turnover
- CSF secretion in the developing brain
- CSF:plasma ratio in opossum (2)
- Establishment of ion gradients CSF:plasma
- Ion gradient in brain development
- Chloride gradient in rats
- Effective barrier mechanisms in developing brain
- Adult ion transfer
- Transporter expression in embryo choroid plexus
- AQP1 - lateral ventricle (rat)
- Lateral ventricular volume
- High concentration of proteins in CSF
- Protein concentration in CSF (rat)
- High protein levels exert an osmotic effect
- Strap junctions
- Freeze fractures of strap and tight junctions
- TEM of strap and tight junctions
- Protein positive epithelial cells, LV choroid plexus
- P6 M. domestica: albumin in choroid plexus
- Expansion of the ventricular system
- Summary
- Acknowledgements
- References
Topics Covered
- The brain barriers
- Historical perspective
- Morphology of cerebral blood vessels and choroid plexus in the development brain
- Are tight junctions functionally tight?
- Ion and water transfer mechanisms
- Origin and significance of high CSF protein concentration in embryos
- CSF-brain barrier in the developing brain
Talk Citation
Saunders, N. (2009, November 19). Barrier mechanisms in the developing brain: mechanisms and misunderstandings [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/XZBH4186.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Norman Saunders has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Barrier mechanisms in the developing brain: mechanisms and misunderstandings
A selection of talks on Neurology
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