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1. Introduction
2. Disclosures
3. Overview
4. Phosphate is vital for several key biological processes
5. Phosphate homeostasis regulation
6. Key players in phosphate homeostasis
7. Pathophysiology of acute hypophosphataemia
8. Pathophysiology of chronic hypophosphataemia
9. Symptoms of low phosphate
10. Biochemical investigations
11. Disorders of hypophosphataemia
12. Case study 1
13. Case study 1: 3.5-year-old boy
14. Case study 1: clinical presentation
15. Case study 1: biochemical picture
16. Approach to hypophosphataemia
17. Case study 1: management
18. Preventing nutritional rickets
19. Case study 2
20. Case study 2: 3.5-year-old boy
21. Case study 2: progress
22. Case study 2: biochemical picture
23. Approach to hypophosphataemia
24. Differentials of FGF23-mediated hypophosphataemia
25. X-linked hypophosphataemia
26. Autosomal dominant hypophosphataemic rickets
27. ARHR type 1
28. ARHR type 2 (ARHR2)
29. ARHR2
30. ARHR type 3 (ARHR 3)
31. Fibrous Dysplasia (FD)
32. Fibrous dysplasia
33. Tumour-Induced Osteomalacia (TIO)
34. TIO: clinical features
35. TIO & imaging
36. Approach to hypophosphataemia
37. Hypophosphataemic rickets with hypercalciuria
38. Fanconi syndrome
39. Summary

Topics Covered

• The spectrum of hypophosphataemia in children
• Phosphate homeostasis
• Pathophysiology of hypophosphataemia
• Acute and chronic hypophosphataemia
• Management of hypophosphataemia
• Rickets
• Hereditary Hypophosphataemic Rickets with Hypercalciuria (HHRH)
• Tumour Induced Osteomalacia (TIO)
• X linked hypophosphataemia (XLH)
• FGF23-mediated hypophosphataemia
• Autosomal Dominant Hypophosphataemic Rickets (ADHR)
• Autosomal Recessive Hypophosphataemic Rickets (ARHR)
• Fibrous Dysplasia (FD)
• Fanconi syndrome

Links

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

External Links

• Slide 8- Medscape: Hypophosphatemia
• Slide 25- The Biomedical & Life Sciences Collection, Henry Stewart Talks: Thomas Carpenter. X-linked hypophosphataemia: genetics, diagnosis and management

Talk Citation

Publication History

• Published on March 31, 2024

Financial Disclosures

• Honorarium, travel grants and research grants from Alexion, Kyowa Kirin, Novo Nordisk, Sanofi, Internis. Expert panel member on the International Hypophosphataemia Network, a Kyowa Kirin information hub for healthcare professionals