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1. Introduction
2. Mitochondrial disorders and neurodegeneration (1)
3. Mitochondria- essential eukaryotic organelles (1)
4. Mitochondria- essential eukaryotic organelles (2)
5. Mitochondria- essential eukaryotic organelles (3)
6. Mitochondrial DNA (mtDNA)
7. Mitochondrial proteins
8. Bioenergetic pathways
9. The mitochondrial OXPHOS enzyme system
10. The mitochondrial OXPHOS enzyme complexes
11. The L and H strands
12. The mtDNA D-loop
13. Replication of mtDNA
14. BrdU detects DNA replicating DNA
15. mtDNA replication is independent of the cell cycle
16. Initiation of mtDNA replication
17. mtDNA shows maternal inheritance
18. Maternal inheritance of mtDNA molecular basis
19. Mitochondrial disorders and neurodegeneration (2)
20. mtDNA mutations (1)
21. mtDNA mutations (2)
22. The m.3243A>G mtDNA point mutation (1)
23. The m.3243A>G mtDNA point mutation (2)
24. The m.3243A>G mtDNA point mutation (3)
25. Mutations result in a decrease of ATP production
26. mtDNA mutations increrase ROS production
27. mtDNA point mutations show maternal inheritance
28. ART prevent transmission of mtDNA diseases (1)
29. ART prevent transmission of mtDNA diseases (2)
30. Mitochondrial disorders and neurodegeneration (3)
31. Nuclear gene defects in mitochondrial diseases (1)
32. Nuclear gene mutations & defects of mtDNA (1)
33. Nuclear gene mutations & defects of mtDNA (2)
34. Alpers’ disease caused by POLG mutations
35. Nuclear gene mutations & defects of mtDNA (3)
36. Defects of mt deoxynucleotide synthesis
37. BrdU incorporation into replicating DNA
38. Southern blot analysis of quiescent fibroblasts
39. Nuclear gene defects in mitochondrial diseases (2)
40. Friedreich’s ataxia – clinical hallmarks
41. Friedreich’s ataxia – pathogenesis
42. Nuclear gene defects in mitochondrial diseases (3)
43. Hereditary spastic paraplegia – clinical hallmarks
44. Hereditary spastic paraplegia – pathogenesis
45. Nuclear gene defects in mitochondrial diseases (4)
46. Nuclear gene defects in mitochondrial diseases (5)
47. Mitochondrial fission and fusion
48. Nuclear gene defects in mitochondrial diseases (6)
49. Parkinson’s disease – clinical hallmarks
50. Parkinson’s disease – pathological hallmarks
51. Parkinson’s disease – pathogenesis
52. Induction of mitophagy by PINK1 and Parkin
53. Mitochondrial disorders and neurodegeneration (4)

Topics Covered

• Mitochondrial structure and function
• Oxidative phosphorylation
• Mitochondrial DNA (mtDNA) structure, replication and maternal inheritance
• Diseases caused by mutations in mtDNA and therapy
• Diseases caused by mutations in nuclear genes coding for mitochondrial proteins

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on July 31, 2019

Financial Disclosures

• Dr. Jan-Willem Taanman has received consulting fees/honoraria from Novintum Biosciences Ltd., royalties from Abcam, and research support from The Michael J Fox Foundation.