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Printable Handouts
Navigable Slide Index
- Introduction
- Using DNA’s chemical information
- DNA is present in all organisms
- Biological material rearranged
- DNA is a nanoscale object
- Alex Rich’s invention of hybridization
- DNA is a topologically linear molecule
- Reciprocal exchange
- Reciprocal exchange in a double helical context
- Design of immobile branched junctions
- 5-Arm, 6-Arm, 8-Arm and 12-Arm Junctions
- Depth, by M.C. Escher
- Sticky-ended cohesion: easily programmed affinity
- Sticky-ended cohesion: structure
- Central concept of structural DNA nanotechnology
- Objectives and applications for our laboratory
- Current crystallization protocol
- Suggestion for producing macromolecular crystals
- Method for organizing nanoelectronic components
- Why DNA?
- Structural and topological assemblies
- Polyhedral catenanes
- Cube
- Truncated octahedron
- Structural assemblies: getting to X, Y, Z
- Construction of crystalline arrays
- Requirements for lattice design components
- Derivation of DX and TX molecules
- 2D DX arrays
- A lattice containing 1 DX tile and 1 DX+J tile
- AFM of a 1 DX tile and 1 DX+J tile lattice
- A lattice containing 3 DX tiles and 1 DX+J tile
- AFM of a 3 DX tiles and 1 DX+J tile lattice
- 2D origami arrays
- Producing patterns from long viral strands
- Various shapes from long viral strands
- Multimer patterns from long viral strands
- Two-dimensional design, one-dimensional result
- Successful two-dimensional design
- Two-dimensionally designed tile
- Two-dimensional result
- Two-dimensional result (zoom)
- Wenyan Liu’s rule
- 3D self-assembled arrays: designed crystals
- A 3D DNA tensegrity triangle
- Threefold pseudosymmetric tensegrity triangle
- The tensegrity triangle motif
- Crystal images
- Crystal structure of the 2-turn tensegrity triangle
- 4Å map perpendicular to a helix
- Environment of a single triangle
- The rhombohedral cavity
- Mono view down 3-fold axis
- Crystalline tensegrity triangles
- Spatial representation
- Two-turn tensegrity triangle with two components
- Movie of the rhombohedral cavity
- Covalent attachment of fluorescent dyes
- Attachment of Cy3 & Cy5 to triangles
Topics Covered
- Hybridization of DNA
- Reciprocal exchange, branched DNA and sticky ends
- Structural DNA nanotechnology
- Polyhedral catenanes
- 2D arrays of tiles
- DNA origami and origami arrays
- 3D self-assembled crystals
Talk Citation
Seeman, N.C. (2016, November 30). DNA: not merely the secret of life 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/SLKX7702.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Nadrian C. Seeman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
DNA: not merely the secret of life 1
Published on November 30, 2016
41 min
A selection of talks on Biochemistry
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Nadrian Seeman,
better known as Ned.
And I'm a professor
at New York University
in the chemistry department.
What I'm going to be
discussing today,
is a field that originated
in our laboratory
and has been growing rapidly
in recent years,
ever since the turn of the century,
and it's called
structural DNA nanotechnology.
0:25
What we do,
is we use the information
in DNA molecule
to make shapes and machines
and even crystals.
And we're hoping
that there are going to be
a large number of applications
of this approach in future years.
We do not talk here about the role
of this approach in living systems
but strictly as a chemical approach
to controlling molecular structure
in the finest possible way
in three dimensions.
0:59
So this slide shows
a series of organisms.
Everybody who's watching this
knows that DNA is the genetic
material of all of them,
the plants, the animals,
the people.
And for the rest of the talk,
I want you to forget
that DNA has a genetic role.
1:19
So the slide shown here
is a chandelier in the cemetery
of the Capuchin monastery
in Rome.
So what we have done here
is captured an example of taking
a natural material, namely bones,
and organizing them in a way
that is not the conventional way
to organize them,
not the way
a skeleton usually looks,
but rather form
an unnatural object,
in this case the chandelier,
so that we have
an arrangement of matter
that we've created with the bones,
but the bones themselves are not
what we're going to be discussing,
but rather the way
that we organize them.