Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Jewish history and genetics
3. Jewish roots and diaspora
4. Babylonian exile
5. Under the Persians
6. After the Roman expulsion
7. Modern times
8. Classification of Jews
9. Jewish subgroups
10. Genetic diseases
11. Population distributions
12. Population specificity
13. Diseases found in Ashkenazim
14. Lysosomal storage diseases (1)
15. Lysosomal storage diseases (2)
16. Diseases in Ashkenazim - four LSDs
17. Genetic drift
18. Heterozygote advantage (selection)
19. Hemoglobinopathies
20. Malaria
21. Arguments for selection
22. Arguments for drift
23. Other diseases affect Ashkenazim
24. Other diseases in Ashkenazim
25. Comparing diseases by group
26. LSDs versus non-LSDs
27. Expected patterns
28. Geographic disparities
29. Ordered frequencies for LSD mutations
30. Ordered frequencies for non-LSD mutations
31. Mutation frequencies
32. Dating mutations
33. Number of generations
34. Dating of various mutations
35. Times of origin
36. LSD and non-LSD are similar
37. Geographic distributions
38. Diseases tested
39. Data analyzed
40. Geographic categories
41. Mutation frequencies for LSDs
42. Mutation frequencies for non-LSDs
43. Frequency of TSD 1421
44. Difference in distribution of LSDs and non-LSDs
45. The TSD-1277 mutation distribution
46. The TSD-1421 mutation distribution
47. The origin of the TSD mutation
48. The genetic drift: explanation for these mutations
49. Conclusions concerning the AJ LSD mutations
50. Bottlenecks in the Jewish population
51. Three bottlenecks
52. Selection versus drift

Topics Covered

• Jewish history and genetics
• Classification of Jews
• Genetic diseases found in Jews, particularly Ashkenazi Jews
• Lysosomal storage diseases
• Natural selection (heterozygote advantage) vs. genetic drift
• Mutation frequencies, ages and geographic distributions
• Bottlenecks in Jewish history

Links

Series:

• Human Population Genetics I

Categories:

• Clinical Practice
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Neil Risch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.