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1. Introduction
2. The lethal effect of radiation in mammalian tissues
3. Sphingomyelin
4. Metabolic pathway of ceramide
5. Smase in the endothelium of proximal aorta
6. Radiation-induced endothelial apoptosis
7. Villus/crypt unit of the small intestine
8. Tissue damage & lethality of mice after RT
9. Differential effect of BM transplantation
10. Apoptosis in irradiated GI villae
11. Apoptotic endothelial cells in the lamina propria
12. Endothelial apoptosis & GI syndrome
13. bFGF abrogates cell death after WBR
14. bFGF treatment delays death induced by radiation
15. RT-induced apoptosis is inhibited in asmase KO
16. Endothelial & paneth cells express FGFR mRNA
17. Direct and indirect effects of radiation
18. Growth patterns of transplanted tumors
19. Effect of RT on 129 transplanted fibrosarcomas
20. RT-induced microvascular endothelial apoptosis
21. Fibrosarcomas implanted into asmase-/- mice
22. Growth pattern of B16F1 melanoma and BAX
23. Marrow derived cells contribute to angiogenesis
24. WT vs. asmase KO donors in WT recipients
25. Bone marrow transplanted from KO to WT mice
26. asmase KO and WT and endothelial apoptosis
27. Isolated asmase-/- tumoral endothelial cells and RT
28. The two-target model for single-dose radiotherapy
29. Future directions/ongoing studies
30. HIF-1 - master regulator of hypoxia-response
31. Radiation-induced reoxygenation & HIF-1-alfa
32. HIF-1 knockdown sensitizes tumor to RT
33. Inhibition of HIF-1 is done post RT
34. The vascular componant of tumor response to RT
35. Collaborators

Topics Covered

• Endothelial apoptosis
• Role in tumor response to radiation therapy
• Tissue damage results from depletion of stem cells and cells with clonogenic capacity
• Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death
• Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation
• Sphingomyelin
• Ceramide
• GI tract and bone marrow: very radiation responsive
• Growth patterns of tumors
• The two-target model for single-dose radiotherapy of experimental tumors
• Engaging the vascular component of tumor response to radiation

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Richard Kolesnick has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.