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1. Introduction
2. Talk outline
3. Cell replacement therapies
4. Parkinson's disease
5. Various symptoms of PD
6. Pathology
7. Symptomatic therapies
8. Alternative: neural transplantation
9. Dopamine cells for PD?
10. How does it work?
11. Early rodent studies
12. Clinical trials: graft survival
13. First PD clinical trials
14. Summary of PD clinical trials
15. Off L-dopa dyskinesia
16. Dyskinesia in transplantation
17. What do we do next?
18. Nigral graft model (PD)
19. Amphetamine-induced rotation
20. Cognitive and motor deficits
21. Stimulus-response learning
22. Nigral grafts in the choice reaction time task
23. Impact of dopamine to serotonin cell ratio
24. Gold standard cell therapy
25. Cell sources
26. Which cells? (PD)
27. Deriving DAergic cells from stem cells
28. ES-derived dopaminergic neurons - in vitro
29. ES-derived dopaminergic neurons - in vivo
30. ES-derived neurons in different animal models
31. Huntington's disease
32. Genetics of HD
33. Neuronal pathology in HD
34. Motor deficits
35. Psychiatric dysfunction
36. Cognitive decline
37. Why transplant in HD?
38. Preclinical studies
39. Striatal grafts in HD: Florida
40. Striatal grafts in HD: Créteil (design)
41. Striatal grafts in HD: Créteil (PET)
42. Striatal grafts in HD: Barker et al., 2014
43. Summary of clinical trials
44. Outstanding Issues for transplantation
45. Striatal graft model (HD)
46. Mechanisms of action
47. Skilled motor behaviour
48. Learning to use the transplant
49. Which cells? (HD)
50. ES-derived medium spiny neurons (design)
51. ES-derived medium spiny neurons (results)
52. Summary
53. Acknowledgments

Topics Covered

• Neural transplantation of primary fetal tissue and stem cells
• Parkinson’s and Huntington’s disease
• Dopaminergic and medium spiny neurons
• Results of clinical trials
• Pre-clinical testing in rodent models of disease

Links

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Lelos, M.J. (2013, November 5). Primary and stem cell transplantation for functional repair of striatal degeneration in Parkinson’s and Huntington’s disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 27, 2024, from https://doi.org/10.69645/UNRZ3517.
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Publication History

• Published on November 5, 2013
• Archived on January 31, 2022

Financial Disclosures

• Dr. Mariah J. Lelos has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.