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Navigable Slide Index

1. Introduction
2. The far-sighted macrophage
3. The near-sighted macrophage
4. A far-sighted receptor mechanism
5. A near-sighted receptor mechanism
6. An inconvenient observation
7. Beta-glucan structure
8. Dectin-1 versus beta-glucan structures
9. Binding of beta-glucan polymers and dectin-1 (1)
10. Binding of beta-glucan polymers and dectin-1 (2)
11. Binding of beta-glucan polymers and dectin-1 (3)
12. Exposing macrophage to beta-glucans
13. Soluble beta-glucans bind to dectin-1
14. Soluble glucans do not work
15. Soluble versus particulate beta-glucans
16. Immobilized glucans trigger dectin-1 signaling
17. Immunological synapse (1)
18. Immunological synapse (2)
19. CD45 and CD148
20. CD45 structure and function (1)
21. CD45 structure and function (2)
22. Do CD45 and CD148 regulate dectin-1 signaling?
23. Dectin-1 and CD45 during phagocytosis
24. Dectin-1 phagocytic synapse (1)
25. Dectin-1 phagocytic synapse (2)
26. Dectin-1 phagocytic synapse (3)
27. Dectin-1 phagocytic synapse: A. fumigatus
28. Dectin-1 signaling model
29. Dectin-1 signaling model: soluble glucans
30. Dectin-1 signaling model: immobilized glucans
31. Cells on glucan-coated plastic vs. control
32. Testing the dectin-1 signaling model
33. CD45 co-immobilization
34. Summary
35. On the term “phagocytic synapse”
36. Do other receptors require phagocytic synapse?
37. Further reading

Topics Covered

• The Phagocytic Synapse
• The ability of Phagocytes to discriminate between particulate ligands and soluble ligands
• The Dectin-1 "phagocytic synapse" as a model mechanism for how a surface receptor can distinguish between a particle and a soluble ligand

Links

Series:

• Cells of the Innate Immune System

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Underhill, D. (2013, November 27). The phagocytic synapse in distinguishing particulate and soluble stimuli [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/TKKF3135.
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Publication History

• Published on November 27, 2013

Financial Disclosures

• Prof. David Underhill has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.