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1. Introduction
2. Overview
3. Archibald E. Garrod
4. What is a gene-environment interaction?
5. For dichotomous outcomes
6. Interaction effects can be described in three ways
7. Quantitative traits
8. Genetic effect for disease traits
9. Removable interaction in risk ratio and log scale
10. Removable interaction in quantitative data
11. Examples of interactions
12. Numerous examples of interaction
13. Example of Eucalia plants
14. Phenylketonuria
15. Gene x environment interactions
16. Genetic basis for weight gain
17. Heritage family study
18. Detecting gene x environment interactions
19. Biological candidate gene approach
20. Limitations of many existing studies of GxE
21. Simply test GWAS main effects for interactions
22. Type 2 diabetes
23. Gene x lifestyle interaction on type 2 diabetes
24. FTO gene
25. FTO gene association with energy balance
26. Difference in BMI between the different genotypes
27. FTO gene x lifestyle interactions in diabetes
28. Possible gene interactions
29. Prospective meta-analysis
30. If gene x environment interactions do not exist
31. Heterogeneity associated with genotype
32. Genotype-based recall randomized clinical trials
33. Genetic population architecture
34. Genotype-based recall trials
35. Possible gene environment mechanisms (1)
36. Possible gene environment mechanisms (2)
37. Concluding remarks

Topics Covered

• Definition of gene-environment interaction
• Examples of interactions and rationale
• Why do we think gene x environment interactions might exist for complex, multifactorial traits?
• How might gene x environment interactions be detected?
• Limitations of many existing studies of gene x environment interactions
• Gene x lifestyle interaction on type 2 diabetes incidence
• Genotype-based recall randomized clinical trials
• What are the likely mechanisms underlying gene x environment interactions?

Links

Series:

• Diabetes in Perspective

Categories:

• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on May 22, 2013

Financial Disclosures

• Prof. Paul Franks has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.