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Printable Handouts
Navigable Slide Index
- Introduction
- Bacterial evasion of phagocyte killing
- Aim of presentation
- The macrophage
- A central part of the immune system
- The neutrophil - effective killer of bacteria
- Phagocytosis - receptor-ligand interactions
- Phagosome maturation and intracellular killing
- Bacterial mechanisms to evade phagocytosis
- The complement system
- Expression of a polysaccharide capsule
- Group B streptococcus (GBS)
- Pathogenesis of neonatal GBS infections
- Polysaccharide capsule - structure and function
- Polysaccharide capsule: antiphagocytic properties
- Streptococcus pyogenes
- Schematic surface structure of S. pyogenes
- M protein - an antiphagocytic surface protein (1)
- M protein - an antiphagocytic surface protein (2)
- M protein - an antiphagocytic surface protein (3)
- Evasion of the complement system
- Evasion of non-opsonic phagocytosis
- Pattern recognition receptors (PRR)
- Scavenger receptor A (SR-A)
- Can the M protein mask the ligands for PRRs?
- Evasion of SR-A mediated phagocytosis
- Targeting of inhibitory receptors
- Human Siglec-5
- GBS beta protein binds Human Siglec-5 (1)
- GBS beta protein binds Human Siglec-5 (2)
- Type III secretion system (1)
- Type III secretion system (2)
- Yersinia T3SS-mediated phagocytosis resistance
- Increased intracellular survival
- M. tuberculosis and phagolysosomal maturation
- L. monocytogenes - escaping the phagosome
- Conclusions
Topics Covered
- Background on phagocytic cells
- The central role of the macrophage in the immune system
- The effectiveness of the neutrophil at killing bacteria
- Phagocytosis
- Receptor-ligand interactions
- Phagosome maturation and intracellular killing
- Different types of phagocytosis and phagocytic killing mechanisms
- Bacterial mechanisms to evade phagocytosis/phagocytic killing: Evasion of complement-mediated phagocytosis, Evasion of non-opsonic phagocytosis, Targeting of inhibitory receptors, Evasion via T3SS , Increased intracellular survival
Links
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Therapeutic Areas:
Talk Citation
Areschoug, T. (2013, January 31). How bacterial pathogens avoid phagocyte killing [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/VSKE4151.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Thomas Areschoug has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Microbiology
Transcript
Please wait while the transcript is being prepared...
0:00
Hi. My name is Thomas Areschoug.
I'm working at the Division
of Medical Microbiology
at Lund University in Sweden.
I will give you a lecture on how
bacterial pathogens
avoid phagocyte killing.
0:15
Bacterial evasion of
phagocyte killing
is an important step in
the pathogenesis of
bacterial disease.
Today, numerous
bacterial mechanisms to
avoid phagocyte killing
have been described
in the literature.
These studies are not
only important for
our understanding of
the molecular pathogenesis
of bacterial disease,
but they may also
reveal which parts of
the host's immune system
are of importance
for host protection
against bacteria.
0:43
The aim of my presentation
is to, first,
give you a brief background
on phagocytic cells.
We'll focus on the macrophages
and the neutrophils.
We will then go through
the different types of
phagocytosis and phagocytic
killing mechanisms.
Finally, I will give
you a few examples of
bacterial mechanisms to evade
phagocytosis and
phagocytic killing,
including both
classical examples
and a few novel mechanisms
described more recently.
1:14
All macrophages
stem from a common
myeloid progenitor cell
in the bone marrow,
which migrates into the blood
and develops into monocytes.
The monocytes then migrate into
various types of
tissues in the body
and differentiate into
resident macrophages
with a distinct phenotype
dependent on the
tissue location.
In the skin, for example,
you find the Langerhans cells,
Kupffer cells in the liver,
osteoclasts in the bone,
and microglia in the
central nervous system.
In the tissues, you can also see
more recently recruited
macrophages that have
been activated by
various stimuli.