Please wait while the transcript is being prepared...
0:00
Hi everyone. My name
is Seon Hee Chang.
I work with Dr. Chen Dong at
the M.D. Anderson Cancer Center.
Our laboratory has been
studying the regulation and
function of the IL-17 cytokine
family and their receptors.
0:18
For the last 10 years,
there has been a lot of
progress in understanding
what IL-17 does to human
health and disease.
Targeting IL-17 by blocking
its cytokine or its receptor has
been pursued by several
different companies
to treat various
autoimmune diseases.
Recently, targeting IL-17
has been very effective,
especially in
treating psoriasis.
0:48
In this presentation,
we will review
various aspects of this
new class of cytokine.
What are IL-17 family cytokines
and how IL-17 family
cytokines are produced?
We will discuss their regulation
and cellular sources.
Once they are produced,
what type of cell do they
target and what type
of molecules do they
produce and what are
the signaling mechanisms
for IL-17 family cytokines?
Overall, how do
the IL-17 family cytokines
impact health and disease,
and what are the remaining
questions to explore?
1:29
The founding member of
the IL-17 family
cytokine is IL-17A also
known as IL-17 which was first
cloned in 1993 and 1995.
It is a secreted
glycosylated protein
with conserved
cysteine residues.
The receptor for IL-17A
or IL-17 receptor A
was first cloned in 1995,
and this protein
is a single-pass,
ubiquitously expressed type
one transmembrane protein.
After IL-17A and
receptor A were found,
the homologous proteins
were identified
and it was named IL-17B,
IL-17C, IL-17D, IL-17E,
and IL-17F and
homologous protein for
IL-17 receptor A were found
and named as receptor B,
receptor C, receptor D,
and receptor E.
