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1. Introduction
2. B. Celli disclaimer
3. Studies in COPD (1)
4. Studies in COPD (2)
5. COPD survival: oxygen
6. BODE index and FEV1 as predictors of mortality
7. The history of chronic bronchitis and emphysema
8. Spirometry and the course of FEV1 progression
9. Spirometry and the curse of FEV1 progression
10. Mean FEV1 values by age, for NS vs. CS
11. Not all COPD decline equally (1)
12. Not all COPD decline equally (2)
13. ECLIPSE study
14. Bronchodilators action
15. Bronchodilators action - illustration
16. Pharmacological trials
17. B. Celli's trials type
18. Salmeterol for the treatment of COPD
19. Tiotropium study
20. Incidences of cardiovascular events - JUPITER trial
21. Death from any cause according to study group
22. Landmark trials
23. The TORCH trial
24. TORCH: rate of decline in FEV1
25. Rate of exacerbations requiring systemic steroids
26. The TORCH trial as a whole
27. The UPLIFT trial
28. Bronchodilator response distribution in UPLIFT
29. UPLIFT: FEV1 versus FVC response
30. The UPLIFT trial as a whole
31. Mortality in TORCH and UPLIFT
32. UPLIFT: pre & post-bronchodilator FEV1 in COPD
33. TORCH - rate of decline in FEV1
34. Annual decline in post-bronchodilator FEV1
35. Salmeterol vs. Tiotropium (POET)
36. Important trials
37. Tiotropium + (Placebo, Salmeterol, or S/F)
38. Tiotropium vs. Tio/Bud/Formoterol (1)
39. Tiotropium vs. Tio/Bud/Formoterol (2)
40. New medications
41. Efficacy and safety of indacaterol (1)
42. Efficacy and safety of indacaterol (2)
43. Indacaterol versus Tiotropium (1)
44. Indacaterol versus Tiotropium (2)
45. Indacaterol provides improvement in trough FEV1
46. Roflumilast in COPD treated with 2 LABD (1)
47. Roflumilast in COPD treated with 2 LABD (2)
48. Change from baseline FEV1 15 days
49. The future and conclusions
50. Recent improvement in survival after hospitalization
51. Conclusions
52. Concluding remarks

Topics Covered

• Landmark studies in COPD
• Action of Bronchodilators
• Pharmacological trials
• The future of COPD treatments

Links

Series:

• Advances in Chronic Obstructive Pulmonary Disease (COPD)

Categories:

• Biochemistry
• Cell Biology
• Pharmaceutical Sciences

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on July 31, 2012

Financial Disclosures

• Prof. Bart Celli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.