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1. Introduction
2. Recognising an invading organism
3. Recognising PAMPS
4. Research in flies
5. TLRs
6. TLR sensing pathogens
7. C-type lectin domain (CTLD)
8. CTLD groups
9. CTLD specific groups
10. MBL
11. MBL functions
12. MBL attack
13. MBL: intracellular signalling
14. Is MBL important?
15. Surfactant proteins
16. Surfactant proteins: functions
17. Triggering inhibitory intracellular signals
18. Are surfactant proteins important?
19. The membrane bound mannose receptor
20. The mannose receptor (MR) structure
21. The mannose receptor (MR) recognition
22. The role of the mannose receptor
23. Is the mannose receptor important?
24. DC-SIGN
25. DC-SIGN structure and recognition
26. Mannose-specific DC-SIGN signalling
27. Fucose-specific DC-SIGN signalling
28. Is DC-SIGN important?
29. Dectin-1
30. Dectin-1 structure
31. Dectin-1 crystal structure
32. Dectin-1 recognition
33. Particle uptake in Dectin-1 transfected cells
34. Innate responses mediated by Dectin-1
35. Dectin-1 recognises live fungal pathogens
36. Dectin-1 non-redundant role in antifungal immunity
37. Role of Dectin-1 in anti-fungal immunity: mouse
38. Human Dectin-1 polymorphism
39. Human Dectin-1 deficiency
40. Role of Dectin-1 in anti-fungal immunity: human
41. Role of Dectin-1 in adaptive immunity
42. Dectin-1 mediated intracellular signalling
43. Syk kinase
44. Dectin-1 triggers Raf-1 pathway
45. Dectin-1 signalling
46. Dectin-1 signalling for cytokine production
47. Collaborative signalling for cytokine production
48. Dectin-1 and TLR-2 are required for TNF induction
49. Chromoblastomycosis and Fonsecaea pedrosoi
50. Co-stimulation in vitro
51. Reason for chronic infection
52. Restoring inflammatory response
53. Repression of other cytokines
54. Co-stimulation affects type of adaptive response
55. Dectin-1 similarity to TLR
56. Dectin-2 and Mincle
57. Dectin-2
58. Is Dectin-2 important?
59. Mincle
60. Dectin-1, Dectin-2 and Mincle similarity to TLR
61. Pathogens recognised by Dectin-2/Mincle
62. Th17 responses and fungal infections
63. Summary
64. Acknowledgements

Topics Covered

• Role of pattern recognition receptors in extracellular pathogen recognition
• TLR and CLR
• Soluble CLRs and opsonisation
• MBL, SPA, SPD
• Membrane CLRs and signal transduction
• Mannose Receptor
• DC-SIGN
• Dectin-1
• Dectin-2
• MINCLE
• Innate and adaptive immune responses

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Prof. Gordon Brown is supported by Wellcome Trust, MRC Centre for Medical Mycology and NIHR Exeter Biomedical Research Centre.