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1. Introduction
2. The toll of infectious diseases
3. The golden age of microbiology
4. How do we kill bacteria?
5. Innate immunity
6. Ilya Metchnikov
7. Toll is important for host defense
8. The Toll-like receptor signal pathway
9. TLRs as pattern recognition receptors
10. Adaptive immunity
11. Innate versus specific immunity
12. The host defense to an infection
13. Th1/Th2 hypothesis and EAE
14. IL-12R vs. IL-23R
15. A new T-helper subset
16. IL-1 and IL-23 drive differentiation of human TH17
17. IL-1 and PGE2 drive differentiation of human TH17
18. A new T-helper subset
19. IL-17 family members
20. The roles of IL-17A and IL-17F
21. The roles of IL-17E
22. IL-22 induces production of defensins
23. Th17 responses in inflammation
24. Are Th17 responses important in humans?
25. Hyper IgE syndrome (1)
26. IFN gamma defect in HIES
27. Th17 populations in HIES
28. Genetic cause: STAT3 mutations
29. Hyper IgE syndrome (2)
30. Autosomal dominant CMC
31. Chronic mucocutaneous candidiasis (1)
32. Chronic mucocutaneous candidiasis (2)
33. Chronic mucocutaneous candidiasis (3)
34. Chronic mucocutaneous candidiasis (4)
35. STAT1 mutation in the CC domain
36. Summary
37. Cunclusions
38. Acknowledgements

Topics Covered

• Resistance to infection
• Involvement of innate and adaptive immune responses
• Innate immunity modulates Th-responses
• Th17 are crucial for mucosal host defense
• Deficiencies in Th17 in patients lead to mucosal fungal and bacterial infections

Links

Series:

• Cells of the Innate Immune System

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. Mihai Netea has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.