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1. Introduction
2. Paramecium (protozoan)
3. Vertebrate cells make two distinct kinds of cilia
4. Distribution of cilia in different organisms
5. Ciliary development is linked with cell cycle
6. How to build the motile cilium
7. The mammals transcription factor Foxj1
8. Motility of nodal cilia and asymmetric development
9. Summary
10. The zebrafish as a model system
11. Zebrafish foxj1a
12. Loss of Foxj1a compromises motile cilia formation
13. Loss of Foxj1a and asymmetry of visceral organs
14. Foxj1a regulates expression of dynein and centrin2
15. Foxj1a induce left-right dynein and centrin2
16. Motile ciliogenic genes are Foxj1a-dependent
17. Promoters of ciliary genes and Foxj1a activity
18. Promoters of ciliary genes and Foxj1a in vivo
19. Foxj1a activity induce ectopic motile cilia-like cilia
20. Tektin- and EFHC1-GFP fusion proteins
21. The Foxj1a induced ectopic cilia are motile
22. Conclusions (1)
23. Primary cilia and hedgehog signaling
24. Hh signaling and patterning of vertebrate embryo
25. Mechanism of Hh signal transduction
26. Hh signaling: connection with primary cilia
27. Activator/repressor forms of Gli
28. Hh pathway components localize to basal bodies
29. Mutation of the igu gene and Hh signaling
30. igu encodes a protein necessary for Gli activity
31. igu gene and primary cilia formation
32. Igu function is required for axonemal biogenesis
33. Motile cilia formation and Igu activity
34. The Igu protein localizes to basal bodies
35. Conclusions (2)
36. Acknowledgements

Topics Covered

• Motile and primary cilia
• Developmental regulation of ciliogenesis
• Role of the Roxj1 transcription factor in motile cilia formation
• Hedgehog signaling and primary cilia
• DZIP1 proteins in ciliary biogenesis

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Categories:

• Physiology & Anatomy
• Reproduction & Development

Talk Citation

Publication History

• Published on August 4, 2010

Financial Disclosures

• Dr. Sudipto Roy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.