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Printable Handouts
Navigable Slide Index
- Introduction
- Peripheral senses
- Sensory organs of an adult Drosophila
- Hearing: Johnston organ and chordotonal organs
- Hearing in Drosophila courtship
- External sensory organs
- Mechanosensory organs
- Chemosensory organs
- Sensory organ development
- Sensory organ lineages
- Early development of PNS organs
- bHLH proneural genes in PNS
- Proneural proteins and Notch signaling
- Notch signaling in the specification of the SOPs
- Senseless is essential for proper SOP formation
- Loss of external sensory organs in a sens mutant
- Sens zinc fingers are highly conserved
- Loss of Scute expression in sens mutant clones
- Results of ectopic expression of senseless
- Senseless synergizes with proneural proteins
- S2 cell transcription assay
- Effect of different sens levels on ac transcription
- Model for transcription activation by senseless
- Senseless summary
- Asymmetric divisions in external sensory lineages
- Sensory lineage in WT and Notch mutations
- Localization of cell fate determinants (1)
- Localization of cell fate determinants (2)
- Sensory lineage in WT and numb mutations
- Sensory lineage in WT and neuralized mutations
- Other proteins invloved in ESO differentiation
- Results of Notch signaling loss
- Notch signaling in vertebrates development
- Aberrant Notch signaling and human diseases
- Finding novel genes involved in Notch signaling
- Increased number of pIIb progeny in mutant clones
- sec15 encodes a component of the exocyst
- Intrinsic determinants localization in sec15 mutant
- Is sec15 required for signal sending/receiving cell?
- Sec15 functions upstream of S3 cleavage of Notch
- Similarities between spdo and sec15 phenotypes
- Phenotype of spdo/sec15 double mutant
- Spdo level/localization in sec15 mutant pI cells
- Spdo level/localization in sec15 mutant pII cells
- Colocalization of spdo and delta (1)
- Colocalization of spdo and delta (2)
- Rab11 levels in the apical areas of sec15 clones
- A model for sec15 function
- Acknowledgements
Topics Covered
- The development of the peripheral nervous system in Drosophila serves as a model system
- Isolate and characterize new genes and proteins that play a key role in neurogenesis and neural differentiation in most organisms
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Talk Citation
Bellen, H. (2018, May 31). The development of the peripheral nervous system in the fruitfly Drosophila [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/NWJF3424.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Hugo Bellen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The development of the peripheral nervous system in the fruitfly Drosophila
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello.
My name is Hugo Bellen.
I'm a member of
the Howard Hughes Medical Institute.
Then I'm currently at
Baylor College of Medicine.
I'll be talking about "The Development
of the Peripheral Nervous System in
the Fruit Fly Drosophila".
And the reason why we
studied the development
of the peripheral nervous system in
the fruit flies is that it has been
an excellent model system to identify
new components that are required for
the formation of neurons and
further development of the nervous system.
Before I describe the development
of the nervous system,
I will introduce you to
the different senses and
how the fruit fly copes
with the different senses.
0:44
There are five peripheral senses, sight,
smell, taste, hearing, and proprioception.
Sight is provided by the eyes and
is not the topic of this lecture today.
Smell is provided by olfactory
receptors in the antenna or
the nose in vertebrates and in humans.
Taste is provided by taste receptors
in the labia of the fruit fly and
the legs, typically the tongue in humans.
Hearing is provided by the johnston organ
in the antenna or the ear in humans.
And proprioception is provided
by external sensory organs that
essentially cover the entire body.
So this is also called
sometimes the sixth sense,
it's the sense by which we sense where
all our different body parts are,
that is, or muscles or
limbs or fingers or toes, etc.
Every organism that moves
needs proprioception and
needs information about where
its different body parts are and
this is provided by
external sensory organs.
Here I'll briefly introduce you to
hearing in the johnston organs and
proprioceptive devices in
the skin of the fruit fly or
in the cuticle of the fruit fly.
Hide