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- Introduction
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63 min
1. Drosophila genetics - the first 25 years- Prof. Dan Lindsley
- Establishment of the Primary Body Axes
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28 min
2. Homeotic genes in Drosophila's bithorax complex - The legacy of Ed Lewis- Prof. Francois Karch
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30 min
- Cell Type Specification and Organ Systems
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63 min
4. From germ cell specification to gonad formation- Prof. Ruth Lehmann
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37 min
5. Drosophila stem cells- Prof. Michael Buszczak
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46 min
6. Legacy of drosophila genetics: female germline stem cells- Prof. Michael Buszczak
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34 min
7. Intestinal stem cell-mediated repair in Drosophila 1- Prof. Tony Ip
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30 min
8. Intestinal stem cell-mediated repair in Drosophila 2- Prof. Tony Ip
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43 min
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34 min
10. Axon guidance in Drosophila- Prof. John Thomas
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35 min
11. Development and physiology of the heart- Prof. Rolf Bodmer
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37 min
12. Identification of host defenses in the Drosophila gut using genome-scale RNAi- Prof. Dominique Ferrandon
- Genome Organization and Function
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53 min
13. The genetic analysis of meiosis in Drosophila melanogaster females- Prof. R. Scott Hawley
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46 min
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36 min
15. Dorsal-ventral patterning of the Drosophila embryo- Prof. Mike Levine
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34 min
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27 min
17. Genome-wide pooled CRISPR screen in arthropod cells- Prof. Norbert Perrimon
- Behavior
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40 min
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54 min
19. Genetics of chemosensory transduction: taste and smell- Dr. Leslie Vosshall
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72 min
20. Cracking the case of circadian rhythms by Drosophila genetics- Prof. Jeffrey C. Hall
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46 min
21. Sleep in Drosophila- Dr. Ralph Greenspan
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91 min
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34 min
23. Drosophila as a model for drug addiction- Prof. Ulrike Heberlein
- Mechanism of Human Disease
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65 min
24. Cross-genomic analysis of human disease genes- Prof. Ethan Bier
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56 min
25. Human neurodegenerative disease: insights from Drosophila genetics- Prof. Nancy Bonini
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21 min
26. Metastasis of Drosophila tumors- Prof. Allen Shearn
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27. Rac-enhanced CAR immunotherapy: RaceCAR- Prof. Denise Montell
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34 min
- Evolution of Adaptive Novelties
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56 min
29. The evolution of morphological novelty- Prof. Nipam Patel
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36 min
30. The genetic architecture of complex traits: lessons from Drosophila- Prof. Trudy Mackay
- Archived Lectures *These may not cover the latest advances in the field
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25 min
31. Using gene expression information to provide insights into patterning and differentiation- Prof. Angelike Stathopoulos
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49 min
32. Regulation of gastrulation in Drosophila- Prof. Dr. Maria Leptin
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31 min
33. microRNA function in stem cells- Prof. Hannele Ruohola-Baker
Printable Handouts
Navigable Slide Index
- Introduction
- Gastrulation in Drosophila
- Studies in humans vs. fly
- Embryonic development: gastrulation is key
- Transcriptional regulation
- Dorsal transcription factor morphogen gradient
- Genes regulated by Dorsal "pattern" the embryo
- Dorsal protein levels control cell fate specification
- Mutants containing 3 distinct levels of Dorsal
- Dorsal patterns the dorsoventral axis of the embryo
- Gene expression patterns in mutant backgrounds
- Microarray and whole-genome expression analysis
- Using microarrays to predict gene expression
- 16 Dorsal target genes
- Identify cis-regulatory sequences
- Combined interactions among transcription factors
- Classes of Dorsal threshold output enhancers
- ChIP-chip analysis
- ChIP-chip: antibodies to Dorsal, Twist, and Snail
- Code for expression along the dorsoventral axis
- The network controlling patterning and gastrulation
- Dorsal-regulated genes
- thisbe: a gene identified using microarrays (1)
- thisbe: a gene identified using microarrays (2)
- Gastrulation movements along the DV axis
- Fibroblast growth factors
- Fibroblast growth factor (FGF) signaling
- FGF-ligands and receptors
- ths and pyr are dynamically expressed
- Improper mesoderm migration in mutant embryos
- ths and pyr are required for heart cell specification
- In mutant embryos heart is not properly formed
- Functions for activation of FGF receptor Heartless
- pyramus and thisbe expression domains
- Fgf ligands have different activity levels
- Why doesn't the mesoderm migrate properly?
- Mesoderm migration - live
- Movement of mesoderm cells
- Individual cells tracks
- Phenotype of pyr and ths double mutants
- Illustration of migrating mesoderm cells
- Summary
- Acknowledgments
Topics Covered
- Gastrulation
- Dorsoventral patterning in the early embryo
- Activation of signaling pathways
- Control of cell movements and differentiation events
- Mesoderm cell spreading and heart cell specification
- FGF signaling during development
Links
Series:
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Talk Citation
Stathopoulos, A. (2008, September 29). Using gene expression information to provide insights into patterning and differentiation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/MHDU5986.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Angelike Stathopoulos has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Using gene expression information to provide insights into patterning and differentiation
A selection of talks on Reproduction & Development
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