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1. Introduction
2. Intracellular protein trafficking
3. Protein maturation in the secretory pathway
4. How proteins first encounter the secretory pathway
5. Processes in the ER
6. Protein modifications (1)
7. Protein modifications (2)
8. Alteration of residues
9. ER glycoforms
10. The glyco-code of the ER
11. Calnexin and calreticulin (1)
12. Crystal structure of calnexin
13. Calnexin and calreticulin binding to HA
14. Calnexin binding cycle (1)
15. Calnexin/calreticulin functions
16. Co-translational folding
17. Average protein synthesis time
18. Influenza hemagglutinin
19. Oxidation of HA
20. HA truncations
21. A model for HA maturation
22. Type I membrane proteins
23. Proteins protecting the nascent chain
24. Qaulity control
25. Loss of function vs. gain of toxicity
26. Diseses involving ER folding and quality control
27. Tyrosinase is a bona fide ERAD substrate
28. Tyr(C85S) is retained in the ER
29. Functional vs. structural
30. Structural determinants that cause retention
31. ER retention signals
32. Calnexin binding cycle (2)
33. GT, or UDP-glucose glycoprotein
34. Degradation of misfolded proteins
35. Importance of carbohydrate trimming
36. EDEM1, a putative mannose-binding protein
37. EDEM1 and degradation of ERAD substrates
38. EDEM1 extracts proteins from the calnexin cycle
39. Summary-maturation and qaulity control in the ER

Topics Covered

• Protein maturation in the secretory pathway
• ER glycoforms
• The glyco-code of the ER
• Calnexin and calreticulin
• Cotranslational folding
• Influenza hemagglutinin
• Oxidation of HA
• HA truncations
• Type I membrane proteins
• Disease states involving ER folding and quality control
• Structural determinants that cause retention
• ER retention signals
• Calnexin binding cycle
• GT or UDP glucose glycoprotein: glycosyltransferase
• Degradation of misfolded proteins
• Carbohydrate trimming
• EDEM1 functions

Links

Series:

• The Endoplasmic Reticulum

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Hebert, D. (2007, October 1). Glycoprotein maturation and quality control in the endoplasmic reticulum [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 27, 2023, from https://hstalks.com/bs/98/.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Daniel Hebert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.