• Introduction
• 30 min
  1. Prions and amyloids: introduction

  • Prof. Reed Wickner
• Mammalian Prions
• 26 min
  2. Transgenic mouse models of prion diseases

  • Prof. Glenn Telling
• 31 min
  3. Mechanism of prion generation in vitro

  • Dr. Surachai Supattapone
• Non-Prion Amyloids
• 48 min
  4. Similarities between prion diseases and other neurodegenerative diseases

  • Prof. John Hardy
• 43 min
  5. Molecular structure of amyloid and prion fibrils: insights from solid state NMR

  • Dr. Robert Tycko
• Yeast Prions
• 42 min
  6. Chaperones and prions

  • Prof. Yury Chernoff
• Beneficial Amyloids
• 52 min
  7. The dark side of amyloid: PMEL, a natural amyloid in melanosome biogenesis

  • Prof. Michael Marks
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  8. Predicting TSE transmission

  • Prof. Jean Manson
• 53 min
  9. Generation and propagation of infectious prions by cyclic amplification of protein misfolding

  • Prof. Claudio Soto
• 30 min
  10. Yeast and fungal prions: a help or a hindrance?

  • Prof. Reed Wickner
• 42 min
  11. [PIN+]: prions beget prions

  • Prof. Susan Liebman
• 36 min
  12. Yeast prions and protein chaperones

  • Dr. Daniel Masison
• 54 min
  13. Mechanisms of yeast prion propagation

  • Prof. Mick Tuite
• 31 min
  14. Propagation and variability of the yeast [PSI+] prion

  • Prof. Michael Ter-Avanesyan
• 43 min
  15. The genetics and biology of the [Het-s] prion of Podospora

  • Prof. Sven Saupe
• 33 min
  16. The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR

  • Prof. Beat Meier

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The interest in yeasts and fungal prions
3. Yeast and fungal prions: a help or a hindrance?
4. Yeast and fungal prions
5. Comparison of prion domains
6. [PSI+] helps resist stress
7. Phenotypic effects of [PSI+] (1)
8. Phenotypic effects of [PSI+] (2)
9. Are yeast prions a help or a hindrance?
10. Infectious entities of yeast
11. Prions in wild Saccharomyces strains
12. Heterokaryon incompatibility requires [Het-s] prion
13. Comment on Het-s
14. [Het-s] serves as a 'meiotic drive' system (1)
15. The meiotic drive phenomenon
16. [Het-s] serves as a 'meiotic drive' system (2)
17. Some "prion domains" cannot be prions
18. Ure2 from various yeasts
19. "Prion domains" that cannot be prions
20. "Prion domains" have non-prion functions
21. Ure2p prion domain required for nitrogen regulation
22. Ure2p turnover: the prion domain sabilizes Ure2p
23. Sup35 prion domain has a non-prion function
24. Rapid evolution of prion domains
25. PrP polymorphism protects from CJD
26. Prion domain variation in Saccharomyces species
27. Sup35 prion domain variation and prion infection
28. Summary
29. Acknowledgements
30. References

Topics Covered

• [URE3] and [PSI+] not found in wild strains indicating they are harmful
• [Het-s] may benefit its host or may result from "meiotic drive"
• Some "prion domains" cannot be prions
• "Prion domains" have non-prion functions
• Rapid evolution of prion domains may protect against infection

Links

Series:

• Prions and Amyloids

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on September 4, 2008
• Archived on February 25, 2021

Financial Disclosures

• Prof. Reed Wickner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.