• Introduction to Calcium Signaling
• 72 min
  1. Introduction to cellular calcium signaling

  • Dr. Martin Bootman
• 20 min
  2. Monitoring Ca2+ concentration in living cells

  • Dr. Marisa Brini
• 30 min
  3. Cell boundary theorem

  • Prof. Eduardo Ríos
• Calcium Influx
• 19 min
  4. Arachidonic acid and store-independent Ca2+ entry

  • Dr. Luca Munaron
• 34 min
  5. Voltage-dependent calcium channels

  • Prof. Annette Dolphin
• 34 min
  6. Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling

  • Prof. Bernd Fakler
• 37 min
  7. Intracellular Ca2+ signaling: calcium influx

  • Prof. Anant Parekh
• 60 min
  8. Molecular identification of the CRAC channel

  • Prof. Michael Cahalan
• 35 min
  9. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility

  • Prof. Marc Freichel
• Calcium Release
• 53 min
  10. The InsP3 receptor calcium release channel

  • Prof. J. Kevin Foskett
• 31 min
  11. Molecular biology of ryanodine receptors: an overview

  • Dr. Christopher George
  • Prof. F. Anthony Lai
• 57 min
  12. cADPR and NAADP: messengers for calcium signalling

  • Prof. Antony Galione
• 43 min
  13. Ryanodine receptors and cardiac function

  • Prof. David Eisner
• Calcium Efflux and Sequestration
• 45 min
  14. Sodium-calcium exchange

  • Prof. John Reeves
• Organelle Calcium
• 42 min
  15. Regulation and role of mitochondrial Ca2+ homeostasis

  • Prof. Rosario Rizzuto
• 54 min
  16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis

  • Dr. Paola Pizzo
  • Dr. Alex Costa
• 34 min
  17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum

  • Dr. Wolfgang Graier
• 26 min
  18. Nuclear calcium signaling

  • Dr. Oleg Gerasimenko
  • Dr. Julia Gerasimenko
• Spatiotemporal Calcium Signals
• 54 min
  19. Regulation of intracellular calcium signaling, localized signals and oscillations

  • Prof. Barbara Ehrlich
• 43 min
  20. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells: introduction and basic concepts

  • Dr. David Friel
• 41 min
  21. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: endoplasmic reticulum, calcium oscillations

  • Dr. David Friel
• 49 min
  22. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: mitochondria, models of spatially non-uniform Ca2+ signals, applications to analysis of experimental results

  • Dr. David Friel
• Calcium Effectors
• 34 min
  23. Neuronal calcium sensor proteins: calcium sensors and regulators of diverse cellular functions

  • Prof. Bob Burgoyne
• 41 min
  24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

  • Prof. Dermot Cooper
• 32 min
  25. Calcium and transcription-coupling

  • Dr. Karen Lounsbury
• 50 min
  26. Cellular calcium (Ca2+) buffers

  • Prof. Dr. Beat Schwaller
• 24 min
  27. Extracellular calcium signaling

  • Dr. Aldebaran M. Hofer
• 50 min
  28. Ca2+, fertilization and egg activation

  • Prof. Karl Swann
• 24 min
  29. Calcium regulation of transcription in plants

  • Prof. Hillel Fromm
• 34 min
  30. Mechanisms regulating STIM expression and function in Ca2+ signaling

  • Dr. Jonathan Soboloff
• 46 min
  31. Dynamic signal encoding in the S. cerevisiae calcium response

  • Dr. Chiraj Dalal
• Calcium and Disease
• 43 min
  32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 28 min
  33. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 38 min
  34. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 47 min
  35. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 46 min
  36. Genetic defects and calcium

  • Prof. Tullio Pozzan
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  37. Calcium, calmodulin and calcineurin

  • Prof. Stephen Bolsover
• 34 min
  38. Calcium flickers steer cell migration

  • Prof. Heping Cheng
• 28 min
  39. Automated Ca2+ imaging of chemosensory neurones in C.elegans

  • Dr. Nikos Chronis
• 46 min
  40. Ca2+ and the regulation of small GTPases

  • Prof. Peter Cullen
• 35 min
  41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo

  • Dr. Michael I. Kotlikoff
• 35 min
  42. Capacitative (store-operated) calcium entry

  • Dr. Jim Putney
• 47 min
  43. The molecular biology of the inositol trisphosphate receptor

  • Dr. Randen Patterson
• 50 min
  44. Coordinated Ca2+ release from intracellular Ca2+ stores

  • Prof. Ole Petersen
• 45 min
  45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology

  • Prof. Ernesto Carafoli
• 60 min
  46. The calcium saga: a matter of life and death

  • Prof. Pierluigi Nicotera
• 22 min
  47. Ca2+ efflux and Ca2+ signals

  • Dr. Anne Green
• 31 min
  48. Organellar calcium pumps of the golgi and ER: from yeast to human

  • Prof. Rajini Rao
• 58 min
  49. Spatial and temporal aspects of cellular calcium signals: 'elementary' signals and waves

  • Prof. Ian Parker
• 26 min
  50. Modeling Ca2+ signals

  • Dr. David Friel

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Modulation of intracellular free Ca concentration
3. IP3 mediated calcium signals
4. Cytoplasm as an excitable medium
5. InsP3-mediated Ca release
6. IP3 receptors family
7. The InsP3R channel is a tetramer
8. Low resolution structures of the IP3 receptor
9. Atomic resolution structures for the IP3 receptor
10. Crystal structure modeling
11. Nuclear patch clamping
12. Single xenopus InsP3R channel
13. Current-voltage relation for InsP3R
14. InsP3R channel activity is regulated by [Ca]i
15. Biphasic manner of Ca regulation of InsP3R
16. Ca dependence of InsP3R: mean open duration
17. Ca dependence of InsP3R: mean closed duration
18. InsP3R channel activity is regulated by InsP3
19. How InsP3 gates the InsP3R channel
20. Na * Po
21. The number of channels activated in a patch (Na)
22. Channel recruitment enables dynamic response
23. The InsP3R channel conductance
24. Inevitable abrupt channel activity termination
25. Ligand concentration-dependence
26. Review
27. Similar channel behaviors in different species
28. Expression of rat type 3 InsP3R in Xenopus
29. Ca activation of types 1 and 3 InsP3R
30. Schematic diagram of Ca signaling elements
31. InsP3R-mediated Ca signaling
32. 3-D surface plot
33. 3-D surface plot of type 1 and 3 InsP3R
34. 3-D surface plot: cell at rest
35. 3-D surface plot: cell stimulated (type 1 channel)
36. 3-D surface plot: cell stimulated (type 3 channel)
37. Calcium induced calcium release
38. Both types 1 and 3 InsP3R propagate Ca release
39. Additional regulatory domains of the channel
40. Effect of free ATP on InsP3R Ca responses
41. The channel sensitivity to ATP changes
42. Is InsP3R localized within multi-protein complexes
43. CaBP1
44. Domain structures of CaBPs and calmodulin
45. Ca dependence of interaction of CaBP and InsP3R
46. The consequences of CaBP binding to the IP3R
47. CaBP1 binding activates InsP3R channel gating
48. Bcl-XL interacts with the IP3 receptor
49. InsP3R channel gating and Bcl-XL
50. Acknowledgements

Topics Covered

• The inositol trisphosphate receptor signaling system
• Dynamic properties of cytoplasmic Ca2+ signals
• Structural properties of the InsP3R
• Patch clamp electrophysiology of the InsP3R channel
• Permeation properties of the channel
• Channel gating regulation by Calcium and InsP3
• Channel mechanisms that account for graded Ca2+ release
• Isoform specific differences in channel gating
• Channel regulation by ATP and interacting proteins

Links

Series:

• Calcium Signaling I
• The Endoplasmic Reticulum

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. J. Kevin Foskett has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.