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1. Introduction
2. Protein secondary structures (1)
3. Secondary structures at protein interfaces
4. Protein secondary structures (2)
5. Etiology of an alpha-helix
6. Main-chain hydrogen bonds in an alpha-helix
7. Alpha-helical domain in biomolecular recognition
8. Short peptides do not adopt defined structures
9. Side chain crosslinked alpha-helices
10. Alpha-helice stability and side chain crosslinking
11. A H-bond surrogate to artificial alpha-helix
12. Issues with the side chain crosslinking methods
13. An alternative to the crosslinking strategy
14. Mimicking the hydrogen bond
15. Main-chain to main-chain distances
16. Two approaches to stabilization of the alpha-helix
17. N-terminal templates for alpha-helices
18. RCM approach to HBS alpha-helices synthesis
19. Immediate goals for the project
20. Solid phase synthesis of artificial helices
21. Metathesis of non-ala-rich helices on solid phase
22. Evaluation of RCM catalysts
23. Standard solid phase synthesis of peptides
24. Solid phase synthesis of artificial alpha-helices
25. Can the HBS method produce short stable helices
26. CD spectra of protein secondary structure
27. CD spectra of the 1 and HBS alpha-helix 2
28. NOEs expected for an alpha-helical structure
29. NOESY spectra and correlation chart of 2
30. Ramachandran plot and secondary structure
31. Amide proton chemical shifts
32. H/D exchange
33. NMR-derived structure of HBS alpha-helix 4
34. Stabilization of the alpha-helical conformation
35. Summary
36. Other approaches to helix mimetics
37. Alpha-peptide oligomers adopt helical conformation
38. Miniproteins that display helical domains
39. Nonpeptidic helix mimetics
40. Conclusions

Topics Covered

• Alpha-helices
• Role of alpha-helices in protein structure
• Alpha-helices in protein-protein and protein-nucleic acids interactions
• Stabilization of short peptides in alpha-helical conformation
• Side-chain cross-linked helices
• Hydrogen-bond surrogate based alpha-helices

Links

Series:

• Chemical Biology

Categories:

• Biochemistry

Talk Citation

Publication History

• Published on August 14, 2008
• Archived on February 25, 2021

Financial Disclosures

• Dr. Paramjit Arora has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.