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1. Introduction
2. Calcium signalling: the beginning
3. Calcium signalling - the idea is born
4. Calcium signalling - early discoveries (1)
5. Calcium signalling - early discoveries (2)
6. Patch-clamp and fluorescent Ca indicators
7. Diversity and versatility of calcium probes
8. Patch-voltage-clamp and Ca indicators combined
9. Calcium as universal signalling molecule
10. Principles of calcium signalling machinery
11. The ER and neuronal calcium signalling
12. Endoplasmic reticulum - the discovery
13. Neuronal ER: morphology and appearance
14. Molecular physiology of ER calcium store
15. Probing for calcium stores
16. Caffeine-induced Ca release - the beggining
17. Intracellular origin of caffein-induced Ca release
18. A view from the lumen of Ca release
19. Concentration dependance and "quantal" behaviour
20. Ca-induced Ca release - initial evidence
21. Ca-induced Ca release - UT recordings
22. Ca-induced Ca release - intraluminal Ca recordings
23. CICR is graded by Ca entry
24. InsP3-induced Ca release - the beginning
25. Activation by neurotransmitters
26. Concentration dependence
27. The neuronal ER is a functionally single Ca store
28. Homogeneity of the ER Ca store (1)
29. Homogeneity of the ER Ca store (2)
30. Evidence for single vs. separate ER Ca store
31. Intraluminal Ca controls ER Ca homeostasis
32. Magnitude and velocity of calcium release
33. SERCA-mediated Ca uptake
34. Molecular basis for [Ca]L-dependent regulation
35. Luminal Ca controls ER Ca uptake
36. Endoplasmic reticulum and synaptic transmission
37. Controlling pre- and post-synaptic Ca signalling
38. Presynaptic RyR-mediated Ca release
39. Presynaptic expression of CICR mechanism
40. Postsynaptic expression of CICR mechanism
41. Ca release through InsP3Rs sets cerebellar LTD
42. The ER as an integrating signalling organelle
43. ER dysfunction and neurodegeneration
44. ER and neuropathology
45. Chronic changes in ER Ca level trigger cell death
46. Neuronal pathology affects releasable Ca content?
47. Experimental diabetes effect on ER Ca
48. Intraluminal Ca controls the ER signalling functions

Topics Covered

• Endoplasmic reticulum
• Calcium signaling
• Intracellular integration
• Calcium waves
• Calcium signal propagation
• Calcium tunnels
• Neuronal signaling
• Intracellular calcium release channels
• Ryanodine receptors (RyR)
• Inositol (1,4,5) trisphosphate receptors (InsP3Rs)
• Endoplasmic reticulum stress
• Neurodegenerative diseases
• Neuronal cell death

Links

Series:

• The Endoplasmic Reticulum

Categories:

• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Verkhratsky, A. (2007, October 1). Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurones [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/EWXB5802.
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Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.