• Statistical Genetics of Complex Diseases
• 38 min
  1. Population genetics considerations

  • Prof. Nan Laird
• 39 min
  2. Gene-by-environment interaction: study designs and analytical methods

  • Prof. L. Adrienne Cupples
• 59 min
  3. Analysis of SNP haplotypes

  • Prof. Lyle Palmer
• 36 min
  4. Statistical issues in epidemiological studies of gene-environment interaction

  • Dr. Peter Kraft
  • Prof. Donna Spiegelman
• Molecular Epidemiology of Pulmonary Diseases
• 57 min
  5. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 34 min
  6. Ethical issues in molecular epidemiology and studies of gene-environment interactions

  • Dr. Richard Sharp
• Autoimmune Diffuse Connective Tissue Diseases
• 29 min
  7. Environmental scleroderma: the evidence for putative triggers

  • Prof. Maureen Mayes
• Drug-Induced Disease
• 35 min
  8. Drug-induced lupus

  • Prof. Evelyn Hess
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  9. Biomarkers of exposure

  • Prof. Thomas Smith
• 43 min
  10. GIS and spatial statistics

  • Prof. Louise Ryan
• 47 min
  11. Gene-by-environment interactions in COPD

  • Prof. Edwin Silverman
• 40 min
  12. Occupational and environmental influences on the development and course of lupus

  • Dr. Glinda Cooper
• 54 min
  13. Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis

  • Prof. Lee Newman
• 29 min
  14. Indians, twins and scleroderma: genetic and genomic studies

  • Prof. Frank Arnett
• 27 min
  15. Gene by environment interaction in asthma

  • Prof. Scott Weiss
• 42 min
  16. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 18 min
  17. Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)

  • Dr. Patricia Fraser
• 47 min
  18. Infectious environmental factors and systemic lupus erythematosus

  • Prof. Judith James

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Systemic lupus erythematosus disease effects
3. Etiology of systemic lupus erythematosus
4. Genetics in SLE
5. Linkages to SLE genes (Feb. 2004)
6. Renal events in SLE
7. Linkage analysis stratified by nephritis
8. Linkages to SLE stratified by clinical features
9. Hormonal influences in SLE
10. Roles of infections in SLE
11. Potential infectious triggers of SLE(1)
12. Potential infectious triggers of SLE(2)
13. Apoptosis in SLE
14. Interferon alpha in SLE
15. Infectious bystander effect and autoimmunity
16. Work hypothesis
17. SLE shared feature - autoantibodies
18. Autoantibodies presence before disease onset
19. Autoantibodies target specific peptides
20. Specific targets in Ro - solid phase peptide assay
21. Specific autoantibody targets in Ro
22. Anti-Ro autoantibodies bind to EBNA-1
23. Order of antibody onset
24. Molecular mimicry
25. Epstein-Barr Virus (EBV)
26. EBNA-1 properties
27. Seropositivity against EBV in pediatrics
28. Seroconversion against herpes viruses in adults
29. Growing evidence for role of EBV in SLE
30. SLE-specific differences in EBV exposure
31. EBNA-1-directed antibodies associated with SLE
32. Evidence for infections role in autoimmunity
33. Acknowledgements

Topics Covered

• Etiology and genetics of SLE
• Hormonal influences in SLE
• Role of infections in SLE
• Infections associated with lupus
• Apoptosis in lupus
• Infectious bystander effects in SLE
• Development of autoantibodies in lupus
• Epitope spreading
• Molecular mimicry
• Epstein-Barr virus and SLE
• Lupus specific differences to pathogens
• Mounting evidence for the role(s) of infections in SLE

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Judith James has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.