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Printable Handouts
Navigable Slide Index
- Introduction
- Systemic lupus erythematosus disease effects
- Etiology of systemic lupus erythematosus
- Genetics in SLE
- Linkages to SLE genes (Feb. 2004)
- Renal events in SLE
- Linkage analysis stratified by nephritis
- Linkages to SLE stratified by clinical features
- Hormonal influences in SLE
- Roles of infections in SLE
- Potential infectious triggers of SLE(1)
- Potential infectious triggers of SLE(2)
- Apoptosis in SLE
- Interferon alpha in SLE
- Infectious bystander effect and autoimmunity
- Work hypothesis
- SLE shared feature - autoantibodies
- Autoantibodies presence before disease onset
- Autoantibodies target specific peptides
- Specific targets in Ro - solid phase peptide assay
- Specific autoantibody targets in Ro
- Anti-Ro autoantibodies bind to EBNA-1
- Order of antibody onset
- Molecular mimicry
- Epstein-Barr Virus (EBV)
- EBNA-1 properties
- Seropositivity against EBV in pediatrics
- Seroconversion against herpes viruses in adults
- Growing evidence for role of EBV in SLE
- SLE-specific differences in EBV exposure
- EBNA-1-directed antibodies associated with SLE
- Evidence for infections role in autoimmunity
- Acknowledgements
Topics Covered
- Etiology and genetics of SLE
- Hormonal influences in SLE
- Role of infections in SLE
- Infections associated with lupus
- Apoptosis in lupus
- Infectious bystander effects in SLE
- Development of autoantibodies in lupus
- Epitope spreading
- Molecular mimicry
- Epstein-Barr virus and SLE
- Lupus specific differences to pathogens
- Mounting evidence for the role(s) of infections in SLE
Links
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Talk Citation
James, J. (2007, October 1). Infectious environmental factors and systemic lupus erythematosus [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/ANZN6244.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Judith James has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.