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Navigable Slide Index

1. Intoduction
2. Predisposition to lupus and scleroderma
3. SLE and SSc
4. Systemic sclerosis
5. Environmental exposure and predisposition to SSc
6. SSc environmental triggers
7. Metabolic pathways of SSc triggers: solvents
8. Solvent exposures and SSc risk
9. Solvent exposures and SSc risk: CYP450 genes
10. Solvent exposures x DME genes interaction
11. Xenobiotic biotransformation pathways
12. GSTT1 null/GSTM1 null x environment interaction
13. Lupus prone U.S populations
14. Lupus prone U.K populations
15. African-Americans vs. European-Americans
16. SLE in African-Americans
17. Environment, genetic and behavioral factors
18. Differential risk in African Americans
19. Lupus risk - behavior
20. Behavioral risk for SLE: smoking
21. Modulation of smoking risk for SLE: DME genes?
22. CYP450/GST x smoking interaction
23. Environmental triggers foe lupus
24. Prevalence gradient hypothesis
25. Hypothesis: environmental triggers for lupus
26. Prevalence gradient: etiologies
27. Faber and Krieg research
28. Differential environment x gene interaction
29. Carolina lupus study
30. UV x GSTM1 null interaction
31. Future studies of differential lupus risk
32. Environmental exposures and autoimmune disease
33. Environmental triggers of SLE and SSc
34. Cellular stress
35. Cellular stress modulation
36. Oxidant: antioxidant imbalance = oxidative stress
37. Oxidative stress: animal and human data
38. Oxidative stress: sequelae
39. Oxidative stress: sequelae - cellular damage
40. Silica: oxidative stress - inflammation
41. Future research areas - OS and autoimmunity
42. Future research areas

Topics Covered

• Epidemiology of lupus and scleroderma
• Racial and ethnic variation in disease susceptibility and expression
• Geographic variation
• Environmental triggers
• Hypothetical disease mechanisms of environmental triggers
• Future research directions

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Fraser, P. (2007, October 1). Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 17, 2025, from https://doi.org/10.69645/YGUX2149.
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Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Dr. Patricia Fraser has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.